{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:42:17Z","timestamp":1793396537308,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004054","name":"King Abdulaziz University","doi-asserted-by":"publisher","award":["IFPRC\u2010050\u2010142\u20102020"],"award-info":[{"award-number":["IFPRC\u2010050\u2010142\u20102020"]}],"id":[{"id":"10.13039\/501100004054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp;amp; Gen Med"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aims to explore the association between the quality of life (QoL) in children with Down syndrome (DS) and its relationship with demographic characteristics of both parents and children. The investigation encompasses five domains: physical and psychological well\u2010being, autonomy and parental relationship, social well\u2010being, and peers, as well as school and the learning environment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>An online questionnaire, the KIDSCREEN\u201027, was used to measure the QoL of 112 families with DS in Saudi Arabia, referred to as \u201cParent\u2010Reported Measures.\u201d Descriptive statistics were analyzed using the Statistical Package for Social Sciences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study found that the QoL of children with DS showed high scores in the psychological well\u2010being, autonomy, parental relations, school, and learning environment domains. However, the physical and social well\u2010being and peer domains had lower scores, although still considered \u201cgood scores.\u201d Family income had a positively significant influence on all QoL domains. Specifically, higher family income was associated with better QoL outcomes, except for social well\u2010being. Parental age was found to influence psychological well\u2010being, while parental education and the relationship between the parent and child influenced social well\u2010being. Lastly, the child's gender was found to have an impact on the school and learning environment domain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study highlights the importance of understanding the impact of the demographic variability of children with DS and their parents on the QoL of their children. It emphasizes the need to address the needs of families with lower incomes and the importance of parental education and relationships with their children in improving social well\u2010being. The findings could aid policymakers and healthcare providers in improving the QoL for families with children who have DS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.2337","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T10:14:26Z","timestamp":1702548866000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Quality of life in children with Down syndrome and its association with parent and child demographic characteristics: Parent\u2010reported measures"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2389-6108","authenticated-orcid":false,"given":"Nuha","family":"Alrayes","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences King Abdulaziz University  Jeddah Saudi Arabia"},{"name":"Princess Al\u2010Jawhara Center of Excellence in Research of Hereditary Disorders King Abdulaziz University  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noha M.","family":"Issa","sequence":"additional","affiliation":[{"name":"Department of Genetic Medicine, Faculty of Medicine King Abdulaziz University  Jeddah Saudi Arabia"},{"name":"Department of Human Genetics, Medical Research Institute Alexandria University  Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar Y.","family":"Alghubayshi","sequence":"additional","affiliation":[{"name":"Saudi Arabia Ministry of Health, Khobar Hospital and Health Centers Management  Al\u2010Khobar Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jumana Y.","family":"Al\u2010Amaa","sequence":"additional","affiliation":[{"name":"Princess Al\u2010Jawhara Center of Excellence in Research of Hereditary Disorders King Abdulaziz University  Jeddah Saudi Arabia"},{"name":"Department of Genetic Medicine, Faculty of Medicine King Abdulaziz University  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwaq Hassan","family":"Alsabban","sequence":"additional","affiliation":[{"name":"Department of Biological Science, Faculty of Sciences King Abdulaziz University  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalal Sameer","family":"Al\u00a0Shaer","sequence":"additional","affiliation":[{"name":"Department of Genetic Medicine, Faculty of Medicine King Abdulaziz University  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem Abdullah","family":"Alyoubi","sequence":"additional","affiliation":[{"name":"Pediatric Department King Abdulaziz University Hospital  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalidah K.","family":"Nasser","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences King Abdulaziz University  Jeddah Saudi Arabia"},{"name":"Princess Al\u2010Jawhara Center of Excellence in Research of Hereditary Disorders King Abdulaziz University  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaser M.","family":"Alkhiary","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Prosthodontics Department, Faculty of Dentistry King Abdulaziz University  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.5772\/60638"},{"issue":"11","key":"e_1_2_11_3_1","first-page":"1211","article-title":"Congenital heart defects in down syndrome patients from western Saudi Arabia","volume":"33","author":"Al\u2010Aama J. 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