{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T05:36:10Z","timestamp":1781242570360,"version":"3.54.1"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T00:00:00Z","timestamp":1513728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003579","name":"University of Toronto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003579","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen & Gen Med"],"published-print":{"date-parts":[[2018,3]]},"abstract":"Abstract<\/jats:title>Purpose<\/jats:title>We sought to determine to what extent the knowledge of carrying a BRCA<\/jats:styled-content>1<\/jats:italic> or BRCA<\/jats:styled-content>2<\/jats:italic> mutation influences the uptake of preventive surgeries in Bahamian women, including bilateral salpingo\u2010oophorectomy and bilateral mastectomy.<\/jats:p><\/jats:sec>Patients and methods<\/jats:title>The study population consisted of 78 female residents of the Bahamas for whom a BRCA<\/jats:styled-content>1<\/jats:italic> or BRCA<\/jats:styled-content>2<\/jats:italic> mutation had been detected between 2004 and 2014. The mean age of the 78 participants at the time of genetic testing was 46\u00a0years (age range 22\u201373\u00a0years). The mean time of follow\u2010up was 4.4\u00a0years.<\/jats:p><\/jats:sec>Results<\/jats:title>Of the 78 study participants, 19 women had a bilateral salpingo\u2010oophorectomy (24%). Seven out of 37 patients who had unilateral breast cancer chose to remove the unaffected contralateral breast (19%). Three of 13 patients with no history of breast cancer chose to have a prophylactic bilateral mastectomy (23%).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Preventive surgery is an acceptable option for a significant proportion of Bahamian women with a BRCA<\/jats:styled-content>1<\/jats:italic> or BRCA<\/jats:styled-content>2<\/jats:italic> mutation. It will be important to identify and reduce barriers to preventive surgery in the Bahamas in order that the benefit of getting testing can be fully realized.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.363","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T04:49:47Z","timestamp":1513831787000},"page":"301-304","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Short report: Follow\u2010up of Bahamian women with a BRCA1<\/i> or BRCA2<\/i> mutation"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5798-0626","authenticated-orcid":false,"given":"Steven A.","family":"Narod","sequence":"first","affiliation":[{"name":"Women's College Research Institute Women's College Hospital Toronto ON Canada"},{"name":"Dalla Lana School of Public Health University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raleigh","family":"Butler","sequence":"additional","affiliation":[{"name":"Department of Oncology Princess Margaret Hospital Nassau Bahamas"},{"name":"Department of Obstetrics and Gynecology Princess Margaret Hospital Nassau Bahamas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Bobrowski","sequence":"additional","affiliation":[{"name":"Women's College Research Institute Women's College Hospital Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad R.","family":"Akbari","sequence":"additional","affiliation":[{"name":"Women's College Research Institute Women's College Hospital Toronto ON Canada"},{"name":"Dalla Lana School of Public Health University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DuVaughan","family":"Curling","sequence":"additional","affiliation":[{"name":"Department of Oncology Princess Margaret Hospital Nassau Bahamas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Lunn","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Doctors Hospital Nassau Bahamas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Ho","sequence":"additional","affiliation":[{"name":"Women's College Research Institute Women's College Hospital Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Panahi","sequence":"additional","affiliation":[{"name":"Women's College Research Institute Women's College Hospital Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia","family":"Llacuachaqui","sequence":"additional","affiliation":[{"name":"Women's College Research Institute Women's College Hospital Toronto ON 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12132"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1237"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-09-0171"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.53.2820"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.07.4922"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g226"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-011-1941-0"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.04.188"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12602"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12468"}],"container-title":["Molecular 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