{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T11:43:56Z","timestamp":1770291836242,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T00:00:00Z","timestamp":1539216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Montpellier University Hospital"},{"name":"Les Sapins de Noel des Cr\u00e9ateurs de Paris et du Luxembourg"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen & Gen Med"],"published-print":{"date-parts":[[2018,11]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>General practitioners (GP<\/jats:styled-content>s) have an increasing role in referring patients with putative mutation in BRCA<\/jats:styled-content>1\/2<\/jats:italic> genes for genetics consultation and for long\u2010term follow\u2010up of mutation carriers.<\/jats:p><\/jats:sec>Methods<\/jats:title>We compared the expectations of the GP<\/jats:styled-content>s\u2019 role according to BRCA<\/jats:styled-content>1\/2<\/jats:italic> mutation carriers and to GP<\/jats:styled-content>s themselves.<\/jats:p><\/jats:sec>Results<\/jats:title>Overall, 38% (58\/152) of eligible GP<\/jats:styled-content>s and 70% (176\/252) of eligible patients were surveyed. Although 81% of GP<\/jats:styled-content>s collected the family history, only 24% considered that they know criteria indicating genetics consultation and 39% sufficient knowledge of BRCA<\/jats:styled-content>1\/2<\/jats:italic> guidelines to answer patients\u2019 questions. Twelve% of GP<\/jats:styled-content>s were aware of the French national guidelines. Among unsatisfied patients, 40% felt that their GP<\/jats:styled-content> was able to answer (moderately, sufficiently, or completely) specific questions about BRCA<\/jats:styled-content>1\/2 care as compared with 81% in satisfied patients. Only 33% of GP<\/jats:styled-content>s reported being informed directly by the geneticist about the patients\u2019 results. GP<\/jats:styled-content>s\u2019 main expectations for their role in BRCA<\/jats:styled-content>1\/2 carrier care were psychological support and informing relatives about screening (72% and 71%, respectively), which contrasts with the perceptions of patients, who mainly requested medical advice for BRCA<\/jats:styled-content>1\/2<\/jats:italic>\u2010related care (51%).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>There is an important need for GP<\/jats:styled-content> training and enhancing interactions between GP<\/jats:styled-content>s and geneticists to improve the GP<\/jats:styled-content>'s role in BRCA<\/jats:styled-content>1\/2<\/jats:italic> screening and management.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.464","type":"journal-article","created":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T23:35:29Z","timestamp":1539300929000},"page":"957-965","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Role of the general practitioner in the care of BRCA1<\/i> and BRCA2<\/i> mutation carriers: General practitioner and patient perspectives"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7595-7243","authenticated-orcid":false,"given":"Pierre","family":"Vande Perre","sequence":"first","affiliation":[{"name":"Department of Cancer Genetics Montpellier University Hospital (CHRU) Montpellier France"},{"name":"Universit\u00e9 Toulouse III Paul Sabatier Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Toledano","sequence":"additional","affiliation":[{"name":"Department of Cancer Genetics Breast Disease Center Saint Louis Hospital Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carole","family":"Corsini","sequence":"additional","affiliation":[{"name":"Department of Cancer Genetics Montpellier University Hospital (CHRU) Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsa","family":"Escriba","sequence":"additional","affiliation":[{"name":"Department of Cancer Genetics Montpellier University Hospital (CHRU) Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marine","family":"Laporte","sequence":"additional","affiliation":[{"name":"Department of Cancer Genetics Montpellier University Hospital (CHRU) Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Bertet","sequence":"additional","affiliation":[{"name":"Epidemiology and Clinical Research Department INSERM U1411 Clinical Investigation Centre Montpellier University Hospital 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