{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T19:38:00Z","timestamp":1791833880313,"version":"4.3.4"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T00:00:00Z","timestamp":1537315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Outstanding Scientific Fund of Shengjing Hospital"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp; Gen Med"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of our study was to compare the incidence of chromosomal abnormalities of fetuses with isolated fetal ventriculomegaly (VM) to that of fetuses with the sole risk factor of being born to mothers of advanced age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This prospective study included two groups. Group 1 included fetuses with isolated VM and were further categorized according to maternal age, fetal gender, laterality of VM (unilateral or bilateral), evolution of VM (resolved or persistent or progressive), and the gestational age at the time of diagnosis (&lt;28w or \u226528w). Group 2 were fetuses without any fetal structural abnormality, but maternal age was at or over 35\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Eighteen fetuses (18\/231, 7.8%) with chromosomal abnormalities were identified for Group 1, and 13 fetuses (13\/782, 1.7%) were identified for Group 2. When cases with mothers of advanced age were excluded from Group 1, the incidence of chromosomal abnormalities of isolated VM fetuses age was 7.2%, which is still higher than that of normal structural fetuses in mothers of advanced age (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The risk of chromosomal abnormalities for fetuses with isolated VM is high, especially when it is severe, bilateral, the first presence occurs in mid\u2010gestation and is not resolved.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.477","type":"journal-article","created":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T11:54:55Z","timestamp":1537358095000},"page":"1015-1020","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Presence of chromosomal abnormalities in fetuses with isolated ventriculomegaly on prenatal ultrasound in China"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8436-4228","authenticated-orcid":false,"given":"Dan","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Ultrasound Shengjing Hospital of China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ailu","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Shengjing Hospital of China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Shengjing Hospital of China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Women's and Children's Hospital Dandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Women's and Children's Hospital Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000327157"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(91)90530-5"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970040704"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/01443615.2014.896885"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1080\/jmf.10.4.258.263","article-title":"The degree of antenatal ventriculomegaly is related to pediatric neurological morbidity","volume":"10","author":"Graham E.","year":"2001","journal-title":"Journal of Maternal\u2010Fetal and Neonatal Medicine"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970150509"},{"issue":"6","key":"e_1_2_6_8_1","first-page":"797","article-title":"Maternal age\u2010specific rates of 47,+21 and other cytogenetic abnormalities diagnosed in the first trimester of pregnancy in chorionic villous biopsy specimens: Comparison with rates expected from observations at amniocentesis","volume":"42","author":"Hook E. 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