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Our previous studies reported <jats:italic>PAX1<\/jats:italic> as hypermethylated in cervical cancer tissues, thereby suggesting it as a potential screening marker. Recently, an increasing number of studies have confirmed <jats:italic>PAX1<\/jats:italic> methylation as a promising biomarker in cervical cancer based on its excellent discriminatory ability between high\u2010grade cervical lesions and normal tissues, resulting in a reduced necessity for referral for colposcopy and biopsy. Additionally, <jats:italic>PAX1<\/jats:italic> is also hypermethylated in other tumors, including those associated with epithelial ovarian cancer, esophageal squamous cell carcinoma, head and neck squamous cell carcinoma, and endometrial carcinoma, and shows relatively good sensitivity and specificity for the detection of these tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This review summarizes reports of <jats:italic>PAX1<\/jats:italic> methylation and its promising role in cancer screening, especially that associated with cervical cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>According to current evidence, combined testing for human papillomavirus and <jats:italic>PAX1<\/jats:italic> methylation analysis represents an efficacious cervical cancer\u2010screening protocol.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.506","type":"journal-article","created":{"date-parts":[[2019,1,13]],"date-time":"2019-01-13T05:08:48Z","timestamp":1547356128000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["The promising role of <i>PAX1<\/i> (aliases: <i>HUP48<\/i>,<i> OFC2<\/i>) gene methylation in cancer screening"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9898-4893","authenticated-orcid":false,"given":"Chao","family":"Fang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology The Third Xiangya Hospital of Central South University Changsha China"},{"name":"Postdoctoral Research Workstation of Clinical Medicine The Third Xiangya Hospital, Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai\u2010Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The Third Xiangya Hospital of Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Ligh","family":"Liou","sequence":"additional","affiliation":[{"name":"Xiangya Medical Laboratory Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Hua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The Third Xiangya Hospital of Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The Third Xiangya Hospital of Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai\u2010Ming","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The Third Xiangya Hospital of Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001777"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2006-0046"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.55.4.244"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408840102"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000054"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21758"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2016.09.30"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24958"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2016.09.007"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1115"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90026-8"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-10-0096"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.950190905"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2008.12.001"},{"issue":"1","key":"e_1_2_8_16_1","first-page":"45","article-title":"Human papillomavirus in carcinogenesis of cervical cancer","volume":"44","author":"de Silva N. 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