{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T11:13:59Z","timestamp":1760267639047,"version":"3.41.2"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T00:00:00Z","timestamp":1544572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81160228","81260284","81660378"],"award-info":[{"award-number":["81160228","81260284","81660378"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp; Gen Med"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Osteonecrosis of the femoral head (<jats:styled-content style=\"fixed-case\">ONFH<\/jats:styled-content>) is a refractory disease which frequently occurs in young and middle\u2010aged people. Recent studies indicated that <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u201014 played an important role in the development of chondrocytes, metabolism of osteoblasts as well as fate decision of hypertrophic chondrocytes. The aim of this study was to investigate the association between polymorphisms of <jats:italic><jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u201014<\/jats:italic> and steroid\u2010induced osteonecrosis of the femoral head in the Chinese population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We selected 7 <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s (rs3751488, rs1003349, rs1042703, rs2236302, rs1042704, rs2236303, and rs2236304) on gene <jats:italic><jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u201014<\/jats:italic>. Odds ratios (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>s) and 95% confidence intervals (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>s) were estimated using the chi\u2010squared test, genetic model analysis, haplotype analysis, and stratification analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We discovered that the genotype \u201cG\/G\u201d of rs2236302 was associated with <jats:styled-content style=\"fixed-case\">ONFH<\/jats:styled-content> risk in the <jats:italic><jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u201014<\/jats:italic> in the codominant model (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a08.62, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01.07\u201369.46, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.038) and recessive model (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a08.86, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01.10\u201371.31, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.013).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We have confirmed that the susceptive <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s (rs2236302) of <jats:italic><jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u201014<\/jats:italic> from the <jats:italic><jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>s\/<jats:styled-content style=\"fixed-case\">TIMP<\/jats:styled-content>s<\/jats:italic> system exhibit a significant association with increased risk of steroid\u2010induced <jats:styled-content style=\"fixed-case\">ONFH<\/jats:styled-content> in the population of northern China.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.519","type":"journal-article","created":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T01:09:13Z","timestamp":1544663353000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["<i><scp>MMP<\/scp>\u201014<\/i> single\u2010nucleotide polymorphisms are related to steroid\u2010induced osteonecrosis of the femoral head in the population of northern China"],"prefix":"10.1002","volume":"7","author":[{"given":"Yuxin","family":"Qi","sequence":"first","affiliation":[{"name":"Inner Mongolia Medical University Hohhot China"},{"name":"The 2nd Affiliated Hospital of Inner Mongolia Medical University Hohhot China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqi","family":"Wang","sequence":"additional","affiliation":[{"name":"Inner Mongolia Medical University Hohhot China"},{"name":"The 2nd Affiliated Hospital of Inner Mongolia Medical University Hohhot China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingqi","family":"Sun","sequence":"additional","affiliation":[{"name":"The 2nd Affiliated Hospital of Inner Mongolia Medical University Hohhot China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Ma","sequence":"additional","affiliation":[{"name":"The 2nd Affiliated Hospital of Inner Mongolia Medical University Hohhot China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianbo","family":"Jin","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Resource Biology and Modern Biotechnology Northwest University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Inner Mongolia Medical University Hohhot China"},{"name":"The 2nd Affiliated Hospital of Inner Mongolia Medical University Hohhot China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuju","family":"Cao","sequence":"additional","affiliation":[{"name":"Zhengzhou TCM Traumatology Hospital Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4031-1316","authenticated-orcid":false,"given":"Jianzhong","family":"Wang","sequence":"additional","affiliation":[{"name":"The 2nd Affiliated Hospital of Inner Mongolia Medical University Hohhot China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.129510"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3181b1165d"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-17-0075"},{"key":"e_1_2_7_5_1","unstructured":"Chu T. 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