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Our study aimed to explore whether <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>1R1\/<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>1R2<\/jats:italic> polymorphisms influenced <jats:styled-content style=\"fixed-case\">ONFH<\/jats:styled-content> risk in the Chinese Han population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We selected 286 patients and 441 controls, with 11 single\u2010nucleotide polymorphisms in <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>1R1<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>1R2<\/jats:italic> gene were successfully genotyped, and evaluated the associations using the chi\u2010squared test, Fisher's exact test, <jats:italic>T<\/jats:italic> test, and genetic model analyses. Odds ratios and 95% confidence intervals (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>s) were calculated using unconditional logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the allele model, rs11674595 in <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>1R2<\/jats:italic> was associated with increasing the risk of <jats:styled-content style=\"fixed-case\">ONFH<\/jats:styled-content>, the rs10490571 and rs3917225 in <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>1R1<\/jats:italic> gene were associated with an increased risk of <jats:styled-content style=\"fixed-case\">ONFH<\/jats:styled-content>, respectively. In the genetic model, the rs11674595 in <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>1R2<\/jats:italic> gene was associated with an increased risk of <jats:styled-content style=\"fixed-case\">ONFH<\/jats:styled-content> in the codominant model, dominant model, and log\u2010additive model, respectively. The rs10490571 and rs3917225 in <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>1R1<\/jats:italic> gene conferred an increased risk of <jats:styled-content style=\"fixed-case\">ONFH<\/jats:styled-content> in the codominant model, dominant model, and log\u2010additive model, respectively. We found none of the haplotypes in the <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>1R2<\/jats:italic> gene was significantly associated with the<jats:styled-content style=\"fixed-case\">ONFH<\/jats:styled-content> risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings have demonstrated that the rs11674595 (<jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>1R2<\/jats:italic>), rs10490571, and rs3917225 (<jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>1R1<\/jats:italic>) were significantly associated with increasing the <jats:styled-content style=\"fixed-case\">ONFH<\/jats:styled-content> risk in the Chinese Han 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