{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T06:22:57Z","timestamp":1770963777514,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T00:00:00Z","timestamp":1548720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shaanxi Science and Technology Development Plan Project","award":["2013K12-17-03"],"award-info":[{"award-number":["2013K12-17-03"]}]},{"name":"Shaanxi Science and Technology Development Plan Project","award":["2015SF025"],"award-info":[{"award-number":["2015SF025"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp; Gen Med"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Steroid\u2010induced osteonecrosis of the femoral head (ONFH) is a debilitating disease characterized by the activation and infiltration of macrophages into the necrotic site. Interleukin\u20104 (<jats:italic>IL\u20104<\/jats:italic>) administration helped reduce the infiltration of M1 phenotypic macrophages and maintain the activation of M2 phenotypic macrophages, resulting in restriction of inflammation and decrease in osteocyte apoptosis. The aim of this study was to investigate the associations of polymorphisms of <jats:italic>IL\u20104<\/jats:italic> gene with steroid\u2010induced ONFH in Chinese patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>A total of 286 steroid\u2010induced ONFH patients and 441 healthy controls were enrolled. We evaluated 6 single nucleotide polymorphisms of the <jats:italic>IL\u20104<\/jats:italic> gene in this case\u2013control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified rs2243283 in the <jats:italic>IL\u20104<\/jats:italic>gene was potentially associated with an increased risk of steroid\u2010induced ONFH in the dominant model (<jats:italic>p\u00a0=\u00a0<\/jats:italic>0.034; odds ratio [OR]: 1.40; 95% confidence intervals [CI]: 1.03\u20131.91) and in the log\u2010additive model (<jats:italic>p\u00a0=\u00a0<\/jats:italic>0.04; OR: 1.31; 95% CI: 1.01\u20131.71) adjusted by age and gender. Furthermore, we also observed a protective effect of rs2243289 in the dominant model (<jats:italic>p\u00a0=\u00a0<\/jats:italic>0.024; OR: 0.70; 95% CI: 0.51\u20130.95) adjusted by age and gender.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings suggested that polymorphisms of <jats:italic>IL\u20104<\/jats:italic> gene may be associated with susceptibility to steroid\u2010induced ONFH.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.563","type":"journal-article","created":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T05:09:52Z","timestamp":1548824992000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["<i>IL\u20104<\/i> gene polymorphisms and their relation to steroid\u2010induced osteonecrosis of the femoral head in Chinese population"],"prefix":"10.1002","volume":"7","author":[{"given":"Tianbo","family":"Jin","sequence":"first","affiliation":[{"name":"Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region, School of Medicine Xizang Minzu University Xianyang China"},{"name":"Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine Xizang Minzu University Xianyang China"},{"name":"Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine Xizang Minzu University Xianyang China"},{"name":"Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education Xi\u2019an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Suizhou Hospital, Hubei University Of Medicine Suizhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education Xi\u2019an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiamin","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education Xi\u2019an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zichao","family":"Xiong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education Xi\u2019an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4100-0261","authenticated-orcid":false,"given":"Zhi","family":"Yang","sequence":"additional","affiliation":[{"name":"Osteonecrosis and Joint Reconstruction Ward, Department of Joint Surgery, Hong Hui Hospital Xi\u2019an Jiaotong University Health Science Center Xi\u2019an China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,29]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"7","article-title":"Association between polymorphisms in interleukins 4 and 13 genes and chronic periodontitis in a Han Chinese population","volume":"2016","author":"Chen D.","year":"2016","journal-title":"BioMed Research International"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-015-3061-7"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004794"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-200404000-00017"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-2838-8_42"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/978-3-642-35767-1_28","article-title":"The ARCO Staging System: Generation and evolution since 1991","author":"Gardeniers J. 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