{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T14:55:12Z","timestamp":1763477712583,"version":"3.41.2"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T00:00:00Z","timestamp":1548720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Nihon University School of Medicine"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp; Gen Med"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Platelet\u2010derived growth factor receptor beta (<jats:italic>PDGFRB<\/jats:italic>) rearrangement has been reported in a number of patients with chronic eosinophilic leukemia (CEL), B\u2010acute lymphoblastic leukemia, myeloproliferative neoplasms, and juvenile myelomonocytic leukemia. Here, we report a case of CEL carrying a novel fusion gene involving <jats:italic>PDGFRB<\/jats:italic> and GRIP and coiled\u2010coil domain containing 2 (<jats:italic>GCC2<\/jats:italic>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patient and methods<\/jats:title><jats:p>A 54\u2010year\u2010old man presenting with a cough and dyspnea was diagnosed with acute eosinophilic pneumonia. Cytogenetic analysis of the bone marrow revealed the presence of t(2;5)(q37;q31). Fluorescence in situ hybridization analysis in the peripheral blood leukocytes revealed the presence of a split signal at <jats:italic>PDGFRB<\/jats:italic> gene. Imatinib treatment was effective, and disappearance of t(2;5)(q37;q31) in the bone marrow was confirmed after three months of imatinib therapy. Whole\u2010genome sequencing was performed in peripheral blood leukocytes collected before imatinib therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A novel fusion gene between exon 22 of <jats:italic>GCC2<\/jats:italic> and exon 12 of <jats:italic>PDGFRB<\/jats:italic> was detected and the presence of <jats:italic>GCC2\u2010PDGFRB<\/jats:italic> was confirmed by PCR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first case report demonstrating the <jats:italic>GCC2<\/jats:italic> gene as a partner of <jats:italic>PDGFRB<\/jats:italic> in the pathogenesis of CEL.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.591","type":"journal-article","created":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T06:05:05Z","timestamp":1548828305000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A novel fusion gene involving <i>PDGFRB<\/i> and <i>GCC2 <\/i>in a chronic eosinophilic leukemia patient harboring t(2;5)(q37;q31)"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9176-1988","authenticated-orcid":false,"given":"Noriyoshi","family":"Iriyama","sequence":"first","affiliation":[{"name":"Division of Hematology and Rheumatology, Department of Medicine Nihon University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromichi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Division of Hematology and Rheumatology, Department of Medicine Nihon University School of Medicine Tokyo Japan"},{"name":"Division of Laboratory Medicine, Department of Pathology and Microbiology Nihon University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromu","family":"Naruse","sequence":"additional","affiliation":[{"name":"Division of Laboratory Medicine, Department of Pathology and Microbiology Nihon University School of Medicine Tokyo Japan"},{"name":"Health Sciences Research Institute, Inc. Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiro","family":"Miura","sequence":"additional","affiliation":[{"name":"Division of Hematology and Rheumatology, Department of Medicine Nihon University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihito","family":"Uchino","sequence":"additional","affiliation":[{"name":"Division of Hematology and Rheumatology, Department of Medicine Nihon University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Division of Hematology and Rheumatology, Department of Medicine Nihon University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhide","family":"Iizuka","sequence":"additional","affiliation":[{"name":"Division of Hematology and Rheumatology, Department of Medicine Nihon University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Hamada","sequence":"additional","affiliation":[{"name":"Division of Hematology and Rheumatology, Department of Medicine Nihon University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0457-4015","authenticated-orcid":false,"given":"Yoshihiro","family":"Hatta","sequence":"additional","affiliation":[{"name":"Division of Hematology and Rheumatology, Department of Medicine Nihon University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Division of Laboratory Medicine, Department of Pathology and Microbiology Nihon University School of Medicine Tokyo Japan"},{"name":"Division of Companion Diagnostics, Department of Pathology of Microbiology Nihon University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masami","family":"Takei","sequence":"additional","affiliation":[{"name":"Division of Hematology and Rheumatology, Department of Medicine Nihon University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020150"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-02-555607"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200420673"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa025217"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2015.3949"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24880"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.919"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07033.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1609324"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2015.11.009"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-017-3067-x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2017.10.011"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M210387200"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.047530"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4950"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-12679-8"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-472X(00)00138-7"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2018.1427855"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergen.2017.03.004"}],"container-title":["Molecular Genetics &amp; 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