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Ocular problems that affect the cornea, trabecular meshwork, sclera, retina, and optic nerve are very common in these patients. However, there was limited literature focusing on comprehensive ocular findings in different types of <jats:styled-content style=\"fixed-case\">MPS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed the clinical ophthalmologic features and electrodiagnostic results of 50 Taiwanese patients with a diagnosis of <jats:styled-content style=\"fixed-case\">MPS<\/jats:styled-content> (34 males and 16 females; age range, 1.1\u201334.9\u00a0years; nine with <jats:styled-content style=\"fixed-case\">MPS<\/jats:styled-content> I, 17 with <jats:styled-content style=\"fixed-case\">MPS II<\/jats:styled-content>, 17 with <jats:styled-content style=\"fixed-case\">MPS IV<\/jats:styled-content>, and seven with <jats:styled-content style=\"fixed-case\">MPS VI<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 44 patients with available data for visual acuity, 15 patients (34%) had a visual acuity of less than 0.5 (6\/12) equivalent in their better eye, including 71% of those with <jats:styled-content style=\"fixed-case\">MPS VI<\/jats:styled-content>, 38% with <jats:styled-content style=\"fixed-case\">MPS IV<\/jats:styled-content>, 29% with <jats:styled-content style=\"fixed-case\">MPS<\/jats:styled-content> I, and 14% with <jats:styled-content style=\"fixed-case\">MPS II<\/jats:styled-content>. Severe corneal opacities existed in 57% of <jats:styled-content style=\"fixed-case\">MPS VI<\/jats:styled-content> patients and 11% of <jats:styled-content style=\"fixed-case\">MPS<\/jats:styled-content> I patients, compared with none for <jats:styled-content style=\"fixed-case\">MPS II<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MPS IV<\/jats:styled-content> patients. Among 80 eyes with available data of refraction, 11 eyes (14%) had myopia (\u2266\u22120.50\u00a0D), 55 eyes (69%) had hyperopia (\u22670.50\u00a0D), and 55 eyes (69%) had high astigmatism (\u22671.50\u00a0D). Ocular hypertension was found in 45% (28\/62) of eyes. There were 16% (14\/90), 11% (10\/90), 13% (12\/90), 31% (27\/86), and 79% (30\/38) of <jats:styled-content style=\"fixed-case\">MPS<\/jats:styled-content> eyes with lens opacities, optic disc swelling, optic disc cupped, retinopathy, and visual pathway dysfunction, respectively. Intraocular pressure was positively correlated with the severity of corneal opacity (<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ocular complications with significant reduction in visual acuity are common in <jats:styled-content style=\"fixed-case\">MPS<\/jats:styled-content> patients. Diagnostic problems may arise in these patients with severe corneal opacification, especially for those with <jats:styled-content style=\"fixed-case\">MPS VI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MPS<\/jats:styled-content> I.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.617","type":"journal-article","created":{"date-parts":[[2019,3,8]],"date-time":"2019-03-08T08:14:28Z","timestamp":1552032868000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Ophthalmologic manifestations in Taiwanese patients with mucopolysaccharidoses"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9619-0990","authenticated-orcid":false,"given":"Hsiang\u2010Yu","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Medicine Mackay Medical College New Taipei City Taiwan"},{"name":"Department of Pediatrics Mackay Memorial Hospital Taipei Taiwan"},{"name":"Department of Medical Research Mackay Memorial Hospital Taipei Taiwan"},{"name":"Mackay Junior College of Medicine, Nursing and Management Taipei Taiwan"},{"name":"Department of Medical Research China Medical University Hospital China Medical University Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Chun","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Mackay Memorial Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee\u2010Jen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Mackay Memorial Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan\u2010Chieh","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Buddhist Tzu Chi General Hospital Hualien Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010I","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Mackay Memorial Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dau\u2010Ming","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pao Chin","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kaohsiung Veterans General Hospital Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Hui","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Chi Mei Medical Center Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuh\u2010Liang","family":"Hwu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Kuang","family":"Chuang","sequence":"additional","affiliation":[{"name":"Department of Medical Research Mackay Memorial Hospital Taipei Taiwan"},{"name":"College of Medicine Fu\u2010Jen Catholic University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuan\u2010Pei","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medicine Mackay Medical College New Taipei City Taiwan"},{"name":"Department of Pediatrics Mackay Memorial Hospital Taipei Taiwan"},{"name":"Department of Medical Research Mackay Memorial Hospital Taipei Taiwan"},{"name":"Department of Infant and Child Care National Taipei University of Nursing and Health Sciences Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2005.11.007"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6701921"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12607"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2010.02364.x"},{"issue":"5","key":"e_1_2_8_6_1","first-page":"523","article-title":"Ocular findings in children with mucopolysaccharidosis","volume":"50","author":"Campos\u2010Campos L. 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