{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T17:42:37Z","timestamp":1783705357840,"version":"3.55.0"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T00:00:00Z","timestamp":1553212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp;amp; Gen Med"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adverse pregnancy outcomes (APOs) are involved in a series of abnormal pregnancies like embryo growth arrest, spontaneous abortion, premature birth, stillbirth, fetal malformation, birth defects and other pathological pregnancy, and childbirth complications. Polymorphism of methylenetetrahydrofolate reductase gene (<jats:italic>MTHFR<\/jats:italic>, 607093) is one of the main genetic causes of APO. However, there is still debate on whether <jats:italic>MTHFR <\/jats:italic>1298A&gt;C, rs1801131, polymorphism is related to APO. For the lack of extensive research in the Chinese population at present, the study aim to investigate the relationship between <jats:italic>MTHFR<\/jats:italic> 1298A&gt;C polymorphism with APO through a large number of data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 241 samples from patients with APO and 117 healthy controls in Yunnan province were used for <jats:italic>MTHFR <\/jats:italic>gene polymorphism analysis, with double fluorescence quantitative polymerase chain reaction (PCR). In consideration of the low frequency of <jats:italic>MTHFR <\/jats:italic>1298C\/C genotype, which might affect the statistic results, further datasets of <jats:italic>MTHFR<\/jats:italic> 1298A&gt;C polymorphism were collected from literature and analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No statistical difference was detected in the frequency of <jats:italic>MTHFR<\/jats:italic>1298A&gt;C polymorphism between two groups in Yunnan. Our data showed that the frequency of <jats:italic>MTHFR<\/jats:italic> 1298A\/A genotype had the decreasing tendency among Chinese population from northern to southern, as well as eastern to western of China. The frequency of <jats:italic>MTHFR<\/jats:italic> 1298A\/C and 1298C\/C genotypes had the adverse tendency. The frequency of <jats:italic>MTHFR <\/jats:italic>1298C\/C genotype was significantly different between two groups in Chinese populations. The significant difference was also observed in the frequency of <jats:italic>MTHFR<\/jats:italic> 1298C\/C polymorphism between two groups from central China and southern China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In summary, our data showed that <jats:italic>MTHFR <\/jats:italic>1298C\/C genotype was one of the important genetic factors of APO in China.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.642","type":"journal-article","created":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T07:40:40Z","timestamp":1553240440000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Polymorphism of <i>MTHFR<\/i> 1298A&gt;C in relation to adverse pregnancy outcomes in Chinese populations"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7969-1179","authenticated-orcid":false,"given":"Hui","family":"Mo","sequence":"first","affiliation":[{"name":"Department of Reproduction and Genetics Kunming Medical University First Affiliated Hospital Kunming, Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Reproduction and Genetics Kunming Medical University First Affiliated Hospital Kunming, Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Reproduction and Genetics Kunming Medical University First Affiliated Hospital Kunming, Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Xi","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Reproduction and Genetics Kunming Medical University First Affiliated Hospital Kunming, Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua\u2010Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Reproduction and Genetics Kunming Medical University First Affiliated Hospital Kunming, Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Reproduction and Genetics Kunming Medical University First Affiliated Hospital Kunming, Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2015.1031104"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2014.895807"},{"issue":"11","key":"e_1_2_6_4_1","first-page":"1","article-title":"MTHFR and MTRR gene polymorphisms involved in folate metabolism and their relations to unexplained recurrent spontaneous abortion in Henan province","volume":"35","author":"Gao J.","year":"2015","journal-title":"Clinical Medicine"},{"issue":"5","key":"e_1_2_6_5_1","first-page":"380","article-title":"Analysis of risk factors for adverse pregnancy outcomes","volume":"19","author":"Hu A. 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