{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T08:11:59Z","timestamp":1783930319039,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T00:00:00Z","timestamp":1554768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T00:00:00Z","timestamp":1554768000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["5U01DD000494-03"],"award-info":[{"award-number":["5U01DD000494-03"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012615","name":"University of Texas Health Science Center at Houston","doi-asserted-by":"publisher","award":["PRIME Award"],"award-info":[{"award-number":["PRIME Award"]}],"id":[{"id":"10.13039\/100012615","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp; Gen Med"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We examined the association between the maternal genotype for celiac disease\u2010associated variants and risk of neural tube defects (NTDs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a case\u2013control study, using data from the National Birth Defects Prevention Study. We evaluated 667 cases (women with an offspring with NTD) and 743 controls (women with an offspring without a birth defect). We classified women as having low, intermediate, or high risk of celiac disease based on human leukocyte antigen (HLA) variants. We used logistic regression to assess the relationship between HLA celiac risk group (low, intermediate, high) and risk of NTDs. Fifteen non\u2010HLA variants (identified from genome\u2010wide association studies of celiac disease) were individually evaluated and modeled additively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There was no association between HLA celiac risk group and NTDs (intermediate vs. low risk: aOR, 1.0; 95% CI, 0.8\u20131.3; high vs. low risk: aOR, 0.8; 95% CI, 0.5\u20131.3). Of the fifteen non\u2010HLA variants, we observed five significant associations after accounting for multiple comparisons. Three negative associations were observed with rs10903122, rs13314993, rs13151961 (aOR range: 0.69\u20130.81), and two positive associations were observed with rs13003464 and rs11221332 (aOR range: 1.27\u20131.73).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>If confirmed, our results suggest that the maternal variants related to celiac disease may be involved in the risk of NTDs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mgg3.688","type":"journal-article","created":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T02:09:36Z","timestamp":1554862176000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Maternal genetic markers for risk of celiac disease and their potential association with neural tube defects in offspring"],"prefix":"10.1002","volume":"7","author":[{"given":"Thanh T.","family":"Hoang","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Human Genetics, and Environmental Sciences UTHealth School of Public Health Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1504-0884","authenticated-orcid":false,"given":"Yunping","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, Center for Precision Environmental Health Baylor College of Medicine Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura E.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Human Genetics, and Environmental Sciences UTHealth School of Public Health Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shreela V.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Human Genetics, and Environmental Sciences UTHealth School of Public Health Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Swartz","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Data Science UTHealth School of Public Health Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Kim","family":"Waller","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Human Genetics, and Environmental Sciences UTHealth School of Public Health Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard H.","family":"Finnell","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, Center for Precision Environmental Health Baylor College of Medicine Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata H.","family":"Benjamin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Human Genetics, and Environmental Sciences UTHealth School of Public Health Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn L.","family":"Browne","sequence":"additional","affiliation":[{"name":"Congenital Malformations Registry New York State Department of Health Albany New York"},{"name":"Department of Epidemiology and Biostatistics University at Albany School of Public Health Rensselaer New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8827-1881","authenticated-orcid":false,"given":"Mark A.","family":"Canfield","sequence":"additional","affiliation":[{"name":"Birth Defects Epidemiology and Surveillance Branch Texas Department of State Health Services Austin Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Lupo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Section of Hematology\u2010Oncology Baylor College of Medicine Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paige","family":"McKenzie","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Texas Southwestern Medical Center Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary M.","family":"Shaw","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Stanford University School of Medicine Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5874-4155","authenticated-orcid":false,"given":"A. J.","family":"Agopian","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Human Genetics, and Environmental Sciences UTHealth School of Public Health Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The National Birth Defects Prevention Study","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1198\/016214508000000841"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.13102"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2016.10.012"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwp226"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1785"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23177"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.543"},{"key":"e_1_2_7_10_1","volume-title":"Food standards: amendment of standards of identity for enriched grain products to require addition of folic acid","author":"Food and Drug Administration","year":"1996"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15393"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jand.2012.12.016"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.113.183079"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.18.2074"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-014-3514-7[doi]"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002270"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.10086"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23384[doi]"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-304110"},{"issue":"1","key":"e_1_2_7_20_1","first-page":"11","article-title":"Predicting susceptibility to celiac disease by genetic risk profiling","volume":"1","author":"Romanos J.","year":"2010","journal-title":"Annales De Gastroenterologie Et D'hepatologie"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(00)00457-7"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.79"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.169.1.345"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.02.017"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng2058"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114086"},{"issue":"01","key":"e_1_2_7_27_1","first-page":"1","article-title":"Updated estimates of neural tube defects prevented by mandatory folic acid fortification\u2014United States, 1995\u20132011","volume":"64","author":"Williams J.","year":"2015","journal-title":"Morbidity and Mortality Weekly Report"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/phr\/116.S1.32"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.10.012"}],"container-title":["Molecular Genetics &amp; 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