{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T11:42:58Z","timestamp":1784115778119,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T00:00:00Z","timestamp":1393200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["20390201"],"award-info":[{"award-number":["20390201"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["20590714"],"award-info":[{"award-number":["20590714"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp;amp; Gen Med"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The functional c.385C&gt;A single\u2010nucleotide polymorphism (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>) in the fatty acid amide hydrolase (<jats:styled-content style=\"fixed-case\">FAAH<\/jats:styled-content>) gene, one of the major degrading enzymes of endocannabinoids, is reportedly associated with anorexia nervosa (<jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>). We genotyped the c.385C&gt;A <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content> (rs324420) in 762 lifetime <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content> and 605 control participants in Japan. There were significant differences in the genotype and allele frequencies of c.385C&gt;A between the <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content> and control groups. The minor 385A allele was less frequent in the <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content> participants than in the controls (allele\u2010wise, odds ratio\u00a0=\u00a00.799, 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 0.653\u20130.976, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.028). When the cases were subdivided into lifetime restricting subtype <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content> with a history of binge eating or purging, only the restricting <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content> group exhibited a significant association (allele\u2010wise, odds ratio\u00a0=\u00a00.717, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.557\u20130.922, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0094). Our results suggest that having the minor 385A allele of the <jats:italic><jats:styled-content style=\"fixed-case\">FAAH<\/jats:styled-content><\/jats:italic> gene may be protective against <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>, especially restricting <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>. This finding supports the possible role of the endocannabinoid system in susceptibility to <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>.<\/jats:p>","DOI":"10.1002\/mgg3.69","type":"journal-article","created":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T18:25:38Z","timestamp":1393266338000},"page":"313-318","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Association of the c.385C&gt;A (p.Pro129Thr) polymorphism of the fatty acid amide hydrolase gene with anorexia nervosa in the Japanese population"],"prefix":"10.1002","volume":"2","author":[{"given":"Tetsuya","family":"Ando","sequence":"first","affiliation":[{"name":"Department of Psychosomatic Research National Institute of Mental Health National Center of Neurology and Psychiatry Kodaira Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naho","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine Kohnodai Hospital National Center for Global Health and Medicine Ichikawa Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Mera","sequence":"additional","affiliation":[{"name":"Division of Psychosomatic Medicine Department of Neurology University of Occupational and Environmental Health Kitakyushu Fukuoka Japan"},{"name":"Department of Psychosomatic Medicine Yahata Kosei Hospital Kitakyushu Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihiro","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine Graduate School of Medical Sciences Kyushu University Fukuoka Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiko","family":"Takei","sequence":"additional","affiliation":[{"name":"Takei Medical Clinic Kagoshima Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiemi","family":"Nakamoto","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine Saitama Social Insurance Hospital Saitama Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Koide","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine Kamibayashi Memorial Hospital Ichinomiya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Hotta","sequence":"additional","affiliation":[{"name":"Health Services Center National Graduate Institute for Policy Studies Minato\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Naruo","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine Nogami Hospital Kagoshima Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Kawai","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine Graduate School of Medical Sciences Kyushu University Fukuoka Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Nakahara","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine Family Hospital Satsuma Satsumasendai Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chikara","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Division of General Medicine Aichi Medical University Hospital Nagakute Aichi Japan"},{"name":"Setoguchi Psychosomatic Clinic Seto Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Nagata","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Osaka City University Graduate School of Medicine Osaka Osaka Japan"},{"name":"Mental Health Clinic of Dr. Nagata at Nanba Osaka Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyoshi","family":"Ookuma","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yufuin Koseinenkin Hospital Yufuin Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Health Service Center Hiroshima University Higashihiroshima Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Yamanaka","sequence":"additional","affiliation":[{"name":"Graduate School of Welfare Society The International University of Kagoshima Kagoshima Kagoshima Japan"},{"name":"Nishihara Hoyouin Kaya Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuo","family":"Kiriike","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Osaka City University Graduate School of Medicine Osaka Osaka Japan"},{"name":"Hamadera Hospital Takaishi Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhei","family":"Ichimaru","sequence":"additional","affiliation":[{"name":"Department of Nutrition School of Home Economics and Science Tokyo Kasei University Itabashi\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine Kohnodai Hospital National Center for Global Health and Medicine Ichikawa Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen","family":"Komaki","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Research National Institute of Mental Health National Center of Neurology and Psychiatry Kodaira Tokyo Japan"},{"name":"School of Health Sciences at Fukuoka International University of Health and Welfare Ohkawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The Japanese Genetic Research Group For Eating Disorders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(02)00257-7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.187"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh216"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.161191698"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2008.10.014"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.05.010"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00059-5"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/YPG.0b013e32809913d8"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm803"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.01.022"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2012.11.001"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2011.00063"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0b013e328356c3c9"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-001-0946-5"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2553"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20462"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300695"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2008.01.004"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2009.00518.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1753-2000-2-33"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2005-0009"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.31082"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.20089"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.082235799"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802954"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1706"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20029"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2010.107"}],"container-title":["Molecular Genetics &amp; Genomic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmgg3.69","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mgg3.69","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mgg3.69","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mgg3.69","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T15:54:44Z","timestamp":1727279684000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mgg3.69"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,24]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1002\/mgg3.69"],"URL":"https:\/\/doi.org\/10.1002\/mgg3.69","archive":["Portico"],"relation":{},"ISSN":["2324-9269","2324-9269"],"issn-type":[{"value":"2324-9269","type":"print"},{"value":"2324-9269","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,24]]},"assertion":[{"value":"2013-09-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-01-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-02-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}