{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:21:45Z","timestamp":1792531305866,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp;amp; Gen Med"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to investigate the association between genetic variants of <jats:italic>ERAP1<\/jats:italic> (OMIM: 606832) and psoriasis vulgaris (PsV) susceptibility in Inner Mongolia Han nationality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>For primary screening, the subjects included 142 PsV cases and 100 healthy controls without psoriasis. The 27 exons of <jats:italic>ERAP1<\/jats:italic> gene were sequenced to screen significant genetic variants. For the validation study, the subjects included 1030 PsV cases and 965 healthy controls. A total of 18 mutations were detected for genetic variants of significance in primary screening and previously reported genetic variants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In primary screening stage, 13 genetic variants of <jats:italic>ERAP1<\/jats:italic> showed an association with psoriasis. A total of 18 genetic variants were typed for the validation, and 12 genetic variants were associated with PsV in Inner Mongolia Han population. Stratified analysis showed significant differences in the allele frequencies of 8 <jats:italic>ERAP1<\/jats:italic> genetic variants in cases with positive family history, and significant differences in allele frequencies among 9 <jats:italic>ERAP1<\/jats:italic> genetic variants in patients with negative family history. A risk haplotype (TCCCTCCAGACC) was significantly associated with PsV, and the most risk haplotype was E730\/K528\/R127\/E56.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>ERAP1<\/jats:italic> gene mutation may be associated with PsV and <jats:italic>HLA\u2010C*06:02<\/jats:italic> in Han nationality in Inner Mongolia. A risk haplotype of four\u2010nonsynonymous mutation (E730\/K528\/R127\/E56) is associated with PsV.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.70021","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T17:40:10Z","timestamp":1732210810000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>ERAP1<\/scp> Gene Variants and Haplotypes Associated With Psoriasis Vulgaris of Han Chinese in Inner Mongolia"],"prefix":"10.1002","volume":"12","author":[{"given":"Xin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Dermatology The Affiliated Hospital of Inner Mongolia Medical University  Hohhot Inner Mongolia China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Affiliated Hospital of Inner Mongolia Medical University  Hohhot Inner Mongolia 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