{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:34:26Z","timestamp":1772120066892,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374313"],"award-info":[{"award-number":["82374313"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp;amp; Gen Med"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Bullous pemphigoid (BP) and atopic dermatitis (AD) are currently thought to be tightly related, yet studies of the mechanisms of co\u2010morbidities are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We obtained GWAS data for BP (<jats:italic>N<\/jats:italic>\u2009=\u2009376,274) and AD (<jats:italic>N<\/jats:italic>\u2009=\u2009796,661) from the Finnish Genetic Research Program dataset and the UK Biobank, separately. Then, the following four analyses were performed: (1) cross\u2010trait linkage disequilibrium score regression (LDSC) to assess the genetic correlation between BP and AD, (2) cross\u2010phenotype association analysis (CPASSOC) to identify multiple effector loci shared by BP and AD, (3) transcriptome\u2010wide association study (TWAS) to determine whether their cross\u2010organizational expression patterns share genes with a common biological mechanism of relevance, and (4) bidirectional Mendelian randomization (MR) analysis to assess bidirectional causal effects of BP and AD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found a positive genetic association between BP and AD (rg\u2009=\u20090.5476, <jats:italic>p<\/jats:italic>\u2009=\u20090.0495) as well as identified four pleiotropic loci and 59 common genes affecting BP and AD. Bidirectional MR analysis suggested that BP promotes the risk of AD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We revealed a genetic link between BP and AD, which is associated with biological pleiotropy and causality. Awareness of the association between BP and AD helps dermatologists manage patients with these illnesses.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.70022","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T13:20:03Z","timestamp":1728912003000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genomic Correlation, Shared Loci, and Causal Relationship Between Bullous Pemphigoid and Atopic Dermatitis: A Large\u2010Scale Genome\u2010Wide Cross\u2010Trait Analysis"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1049-4082","authenticated-orcid":false,"given":"Qing","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology, Chongqing Traditional Chinese Medicine Hospital, Chongqing Clinical Research Center for Dermatology Chongqing Key Laboratory of Integrative Dermatology Research  Chongqing China"},{"name":"The Second Affiliated Hospital Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine)  Guangzhou China"},{"name":"Guangdong Academy of Traditional Chinese Medicine Research Team of Bio\u2010Molecular and System Biology of Chinese Medicine  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuehua","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine Zhanjiang University of Science and Technology  Zhanjiang Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qizhen","family":"Zhuang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine)  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Wu","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine)  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine)  Guangzhou China"},{"name":"Guangdong Academy of Traditional Chinese Medicine Research Team of Bio\u2010Molecular and System Biology of Chinese Medicine  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Lu","sequence":"additional","affiliation":[{"name":"Guangdong Academy of Traditional Chinese Medicine Research Team of Bio\u2010Molecular and System Biology of Chinese Medicine  Guangzhou China"},{"name":"Guangdong\u2010Hong Kong\u2010Macau Joint Lab on Chinese Medicine and Immune Disease Research Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Wu","sequence":"additional","affiliation":[{"name":"Guangdong Academy of Traditional Chinese Medicine Research Team of Bio\u2010Molecular and System Biology of Chinese Medicine  Guangzhou China"},{"name":"Guangdong\u2010Hong Kong\u2010Macau Joint Lab on Chinese Medicine and Immune Disease Research Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juanjuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Chongqing Traditional Chinese Medicine Hospital, Chongqing Clinical Research Center for Dermatology Chongqing Key Laboratory of Integrative Dermatology Research  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangyu","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Chongqing Traditional Chinese Medicine Hospital, Chongqing Clinical Research Center for Dermatology Chongqing Key Laboratory of Integrative Dermatology Research  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Han","sequence":"additional","affiliation":[{"name":"Guangdong Academy of Traditional Chinese Medicine Research Team of Bio\u2010Molecular and System Biology of Chinese Medicine  Guangzhou China"},{"name":"Guangdong\u2010Hong Kong\u2010Macau Joint Lab on Chinese Medicine and Immune Disease Research Guangzhou University of Chinese Medicine  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome  Guangzhou China"},{"name":"State Key Laboratory of Dampness Syndrome of Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2017.03.010"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.01.047"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3406"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.21758"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-1878(200005)22:5<442::AID-BIES6>3.0.CO;2-Q"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3404"},{"key":"e_1_2_11_8_1","first-page":"15","article-title":"Activity of B and D Factors of Complement Alternative Pathway in Children With Atopic Dermatitis","volume":"3","author":"Gora N. V.","year":"2014","journal-title":"Zhurnal Mikrobiologii, Epidemiologii, i Immunobiologii"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3506"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S376845"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00254"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000792"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05473-8"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19580"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1568-1637(03)00025-4"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13091"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-022-02238-y"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00864-22"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10101432"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.5692\/clinicalneurol.cn-000870"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI17891"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14327"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.20743"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1086\/519795"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1979.tb05577.x"},{"issue":"7","key":"e_1_2_11_26_1","first-page":"2746","article-title":"ACTH Receptor, CYP11A1, CYP17 and CYP21A2 Genes Are Expressed in Skin","volume":"81","author":"Slominski A.","year":"1996","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41435-020-0096-6"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2023911"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0099-7"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-022-02372-w"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10481.x"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1721805115"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.12717"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2014.11.011"}],"container-title":["Molecular Genetics &amp; Genomic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mgg3.70022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T18:42:00Z","timestamp":1730140920000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mgg3.70022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":33,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1002\/mgg3.70022"],"URL":"https:\/\/doi.org\/10.1002\/mgg3.70022","archive":["Portico"],"relation":{},"ISSN":["2324-9269","2324-9269"],"issn-type":[{"value":"2324-9269","type":"print"},{"value":"2324-9269","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"2024-04-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70022"}}