{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T15:07:28Z","timestamp":1769353648275,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp;amp; Gen Med"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>This study investigated the impact of the carrier on transferable blastocyst rate and live birth outcomes in couples with structural chromosomal abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Couples were grouped into reciprocal translocation, Robertsonian translocation, or inversions groups, and clinical data were retrospectively analyzed. Preimplantation genetic testing for chromosomal structural rearrangements (PGT\u2010SR) was conducted, and pregnancy outcomes were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Embryo euploidy rates between male and female carriers differed nonsignificantly in the reciprocal translocation and inversion groups but significantly among the three groups. In the Robertsonian translocation group, male carriers had a higher embryo euploidy rate than that of female carriers. Sperm density of male carriers with reciprocal and Robertsonian translocation was significantly lower than that of the female carrier in the same group, whereas the difference was non\u2010significant in the inversion group. The clinical outcomes of embryo transfer post\u2010PGT were similar regardless of the sex of carriers with structural chromosomal abnormalities. Female carriers with Robertsonian translocations displayed a higher risk of producing embryos with chromosomal abnormalities than male carriers. Pregnancy, live birth, and cumulative live birth rates following a PGT\u2010SR cycle were similar, irrespective of chromosomal structural rearrangement type, and carrier sex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings offer valuable information for genetic counseling.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.70050","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T13:38:47Z","timestamp":1735306727000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Influence of the Sex of Translocation Carrier on Clinical Outcomes of Couples Undergoing Preimplantation Genetic Testing"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1269-5316","authenticated-orcid":false,"given":"Zhiping","family":"Zhang","sequence":"first","affiliation":[{"name":"Center of Reproductive Medicine Affiliated Children's Hospital of Shanxi &amp; Women Health Center of Shanxi Medicine University  Taiyuan Shanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayao","family":"Chen","sequence":"additional","affiliation":[{"name":"Center of Reproductive Medicine Affiliated Children's Hospital of Shanxi &amp; Women Health Center of Shanxi Medicine University  Taiyuan Shanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center of Reproductive Medicine Affiliated Children's Hospital of Shanxi &amp; Women Health Center of Shanxi Medicine University  Taiyuan Shanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruiyang","family":"Wei","sequence":"additional","affiliation":[{"name":"Yikon Genomics Company Ltd.  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Liu","sequence":"additional","affiliation":[{"name":"Yikon Genomics Company Ltd.  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dunmei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Yikon Genomics Company Ltd.  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