{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:19:07Z","timestamp":1789165147655,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen & Gen Med"],"published-print":{"date-parts":[[2025,2]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n The\n activin A receptor type 2A<\/jats:italic>\n gene (\n ACVR2A<\/jats:italic>\n ) plays an important role in normal gestation, particularly in decidualization, trophoblastic invasion, and placentation. Although several studies have investigated the association between\n ACVR2A<\/jats:italic>\n maternal variants and preeclampsia (PE) susceptibility; however, controversial results were obtained. Moreover, in none of the previous studies, the role of\n ACVR2A<\/jats:italic>\n fetal variants was explored. The aim of the present study was to investigate the role of\n ACVR2A<\/jats:italic>\n rs1424954 and rs1424941 polymorphisms in PE susceptibility considering the impact of both fetal and maternal genotypes.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n For genotyping of\n ACVR2A<\/jats:italic>\n rs1424954 and rs1424941, we performed TP\u2010ARMS\u2010PCR on 600 samples, including 400 peripheral blood samples from preeclamptic and normal women and 200 umbilical cord blood samples from each group of pregnant women.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Regarding rs1424954, only the fetal genotypes were associated with an increased risk of PE in both dominant and recessive inheritance models (OR\u2009=\u20092.88, 95% CI: 1.58\u20135.25,\n p<\/jats:italic>\n \u2009=\u20090.0005; and OR\u2009=\u20092.43, 95% CI: 1.21\u20134.87,\n p<\/jats:italic>\n \u2009=\u20090.012; respectively). For\n ACVR2A<\/jats:italic>\n rs1424941variant, both maternal and fetal heterozygote genotypes were associated with PE susceptibility (OR\u2009=\u20091.57, 95% CI: 1.02\u20132.04,\n p<\/jats:italic>\n \u2009=\u20090.04; and OR\u2009=\u20091.90, 95% CI: 1.02\u20133.54,\n p<\/jats:italic>\n \u2009=\u20090.04; respectively).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The present study confirmed the role of fetal\n ACVR2A<\/jats:italic>\n polymorphisms in PE pathogenesis for the first time. However, replicated studies in diverse ethnicities are necessary to confirm the role of fetal genotype on susceptibility to PE.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/mgg3.70069","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T07:39:26Z","timestamp":1738568366000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The First Evidence for the Role of\n \n ACVR2A<\/i>\n <\/scp>\n Gene Fetal Genotype in Preeclampsia Susceptibility"],"prefix":"10.1002","volume":"13","author":[{"given":"Asal","family":"Honarpour","sequence":"first","affiliation":[{"name":"Department of Genetics, Faculty of Biology Science North Tehran Branch, Islamic Azad University Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Majd","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Biology Science Islamic Azad University Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9599-6151","authenticated-orcid":false,"given":"Hossein","family":"Sadeghi","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Faculty of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayedhamid","family":"Jamaldini","sequence":"additional","affiliation":[{"name":"Medical Genomics Research Center, Tehran Medical Sciences Islamic Azad University Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Rahimi","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, School of Medicine Iran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paniz","family":"Kazemzadeh","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, School of Medicine Iran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1709-8975","authenticated-orcid":false,"given":"Reza","family":"Mirfakhraie","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Faculty of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran"},{"name":"Hematopoietic Stem Cell Research Center Shahid Beheshti University of Medical Sciences Tehran 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