{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:23:53Z","timestamp":1790789033411,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp;amp; Gen Med"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of our study was to investigate the clinical characteristics, discrepancies in postnatal diagnosis, and outcomes of prenatally diagnosed arachnoid cysts without extra\u2010CNS anomalies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was a multi\u2010center retrospective cohort study from 16 participating university hospitals in South Korea, with patient data pooled from January 2010 to December 2019. This study focused on cases with prenatally diagnosed arachnoid cysts and analyzed postnatal diagnoses related to CNS anomalies, the need for surgery, and clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010seven fetuses with fetal arachnoid cysts were ultimately included in our analysis. These included 27 supratentorial cysts and 10 posterior fossa cysts, with 11 cases (29.7%) presenting associated CNS anomalies. The most common associated anomalies were ventriculomegaly (18.9%) and callosal abnormalities (10.8%). No chromosomal abnormalities were detected during antenatal care. Postnatal regression was observed in 14.8% of supratentorial cysts and 10.0% of posterior fossa cysts. Neurologic complications, present in 21.6% of all cases, were more prevalent in cases with associated CNS anomalies compared to isolated arachnoid cysts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In cases diagnosed with prenatal arachnoid cysts, ventriculomegaly and callosal anomalies are the most commonly associated CNS anomalies. The presence of additional CNS anomalies is the most critical factor affecting neurologic outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.70116","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T09:36:07Z","timestamp":1750066567000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prenatal Diagnosis of Arachnoid Cysts Without Extra\u2010Central Nervous System Anomalies in the Korean Population: A Multi\u2010Center Retrospective Study on Postnatal Diagnosis and Clinical Outcomes"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1027-7981","authenticated-orcid":false,"given":"Subeen","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul Republic of 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Gon","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Keimyung University College of Medicine  Daegu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Hoon","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Korea University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayan","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yonsei University Health System, Yonsei University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Hee","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Samsung Medical Center, Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Ran","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Inha University College of Medicine  Incheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Cheol","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Biomedical Research Institute, Pusan National University College of Medicine  Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung A.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology College of Medicine, Ewha Womans University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Sun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ilsan Paik Hospital, Inje University College of Medicine  Goyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Ju","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medicine, Kyungpook National University  Daegu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Eun","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecolgy Kangnam Sacred Heart Hospital, Hallym University Medical Center, Hallym University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han Sung","family":"Hwang","sequence":"additional","affiliation":[{"name":"Division of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology Konkuk University Medical Center, Konkuk University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0242-1736","authenticated-orcid":false,"given":"Jong Kwan","family":"Jun","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Seoul National University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0116-7959","authenticated-orcid":false,"given":"So Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Ulsan College of Medicine, Asan Medical Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye\u2010Sung","family":"Won","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Ulsan College of Medicine, Asan Medical Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2691-4954","authenticated-orcid":false,"given":"Mi\u2010Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Ulsan College of Medicine, Asan Medical Center  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