{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:35:08Z","timestamp":1790199308791,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015027","name":"Vice Chancellor for Research and Technology, Hamadan University of Medical Sciences","doi-asserted-by":"publisher","award":["140007205960"],"award-info":[{"award-number":["140007205960"]}],"id":[{"id":"10.13039\/501100015027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp;amp; Gen Med"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recurrent Implantation Failure (RIF) is defined as the inability to establish pregnancy despite high\u2010quality embryo transfer after the application of at least three consecutive in\u00a0vitro fertilization (IVF)\/intracytoplasmic sperm injection\u2010embryo transfer procedures. Chromosomal abnormalities are one of the primary reasons for pregnancy failure, miscarriage, and birth defects in both natural conception and IVF pregnancies. This study was to evaluate the incidence of chromosomal abnormalities in peripheral blood samples from 100 couples who experienced RIF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Chromosomal structure analysis was conducted on peripheral blood samples from 100 couples who experienced RIF between 2018 and 2022. Additionally, cytogenetic assessments were conducted on 200 healthy individuals without clinical issues to ensure the accuracy. The GTG\u2010Banding technique was employed in our research.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of the 200 individuals who faced RIF, six (3%) exhibited chromosomal abnormalities, comprising five (83.3%) men and one (16.6%) woman. Translocation was the main type of autosomal structural abnormalities; also, we found one inversion and one pstk \u2010 (population polymorphism). Conversely, no chromosomal abnormalities were detected in the control group. We found chromosomal abnormalities in 3% of study participants who had experienced RIF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Chromosomal abnormalities significantly contribute to RIF. Therefore, it is imperative to conduct cytogenetic screening for both partners before initiating any assisted reproductive technology procedures.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.70137","type":"journal-article","created":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T05:50:13Z","timestamp":1757137813000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Chromosomal Abnormalities in Couples Experiencing Recurrent Implantation Failure in West of Iran: A Case\u2013Control Study"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0550-7217","authenticated-orcid":false,"given":"Atefeh","family":"Asgari","sequence":"first","affiliation":[{"name":"Research Center for Molecular Medicine, Institute of Cancer, Avicenna Health Research Institute (AHRI) Hamadan University of Medical Sciences  Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1724-6432","authenticated-orcid":false,"given":"Amir Mohammad","family":"Salehi","sequence":"additional","affiliation":[{"name":"Student Research Committee, Hamadan University of Medical Sciences School of Medicine  Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2320-4885","authenticated-orcid":false,"given":"Fatemeh","family":"Shahbazi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health Hamadan University of Medical Sciences  Hamadan Iran"},{"name":"Modeling of Noncommunicable Diseases Research Center, Health Sciences &amp; Technology Research Institute Hamadan University of Medical Sciences  Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safieh","family":"Ghahremani","sequence":"additional","affiliation":[{"name":"Cytogenetic Laboratories, Shahid Beheshti Hospital Hamadan University of Medical Sciences  Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebrahim Kamrani","family":"Saleh","sequence":"additional","affiliation":[{"name":"Cytogenetic Laboratories, Shahid Beheshti Hospital Hamadan University of Medical Sciences  Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,5]]},"reference":[{"issue":"1","key":"e_1_2_14_2_1","first-page":"76","article-title":"The Study of GPx1 Pro198Leu Polymorphism in Idiopathic Male Infertility","volume":"22","author":"Ahmadi Mazjin M.","year":"2015","journal-title":"Avicenna Journal of Clinical Medicine"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0242024"},{"issue":"2","key":"e_1_2_14_4_1","first-page":"113","article-title":"Practical Difficulties in Estimating the Prevalence of Primary Infertility in Iran","volume":"13","author":"Akhondi M. 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