{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T21:15:09Z","timestamp":1769289309519,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3600201"],"award-info":[{"award-number":["2022YFC3600201"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp;amp; Gen Med"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Familial premature coronary artery disease (CAD) is often associated with genetic variants. This study investigated potential causal variants in a Chinese pedigree with premature CAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In total, nine family members were included in the study (six CAD patients and three unaffected controls). Whole\u2010exome sequencing (WES) was performed on six family members (including four patients and two unaffected controls), and the candidate variant was further validated by Sanger sequencing in four individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A strong linkage between c.6406C&gt;G (p.Gln2136Glu; NM_005751.5) in\n                      <jats:italic>AKAP9<\/jats:italic>\n                      (A\u2010KINASE ANCHOR PROTEIN 9; OMIM 604001) and premature CAD was detected in the pedigree. Functional analysis revealed that the c.6406C&gt;G variant in\n                      <jats:italic>AKAP9<\/jats:italic>\n                      decreased the interaction between AKAP9 and PRKAR2A. This association was first detected in premature CAD patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our findings indicate that c.6406C&gt;G in the\n                      <jats:italic>AKAP9<\/jats:italic>\n                      gene could be a causal variant for premature CAD in the Chinese population.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mgg3.70159","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T08:42:53Z","timestamp":1769157773000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Novel A\u2010Kinase\u2010Anchoring Protein 9 Variant in Premature Coronary Artery Disease: A Case Series"],"prefix":"10.1002","volume":"14","author":[{"given":"Yuemiao","family":"Jiao","sequence":"first","affiliation":[{"name":"Department of Interventional Center of Valvular Heart Disease Beijing Anzhen Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minxian","family":"Wang","sequence":"additional","affiliation":[{"name":"National Genomics Data Center, China National Center for Bioinformation  Beijing China"},{"name":"Beijing Institute of Genomics Chinese Academy of Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guifen","family":"Qiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College and Beijing Key Laboratory of Drug Target and Screening Research  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Sport Science, Beijing Key Laboratory of Sports Function Assessment and Technical Analysis Beijing Sport University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziwei","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Interventional Center of Valvular Heart Disease Beijing Anzhen Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5005-3861","authenticated-orcid":false,"given":"Yue","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Interventional Center of Valvular Heart Disease Beijing Anzhen Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengqian","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Interventional Center of Valvular Heart Disease Beijing Anzhen Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangyuan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Interventional Center of Valvular Heart Disease Beijing Anzhen Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.08.1002"},{"issue":"2","key":"e_1_2_12_3_1","doi-asserted-by":"crossref","DOI":"10.1093\/function\/zqaf007","article-title":"Phosphatases Control the Duration and Range of cAMP\/PKA Microdomains","volume":"6","author":"Conca F.","year":"2025","journal-title":"Function"},{"issue":"10","key":"e_1_2_12_4_1","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.2174\/1389450116666150416114247","article-title":"Pharmacological Interference With Protein\u2010Protein Interactions of Akinase Anchoring Proteins as a Strategy for the Treatment of Disease","volume":"17","author":"De\u00e1k V. 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