{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T02:00:01Z","timestamp":1769306401579,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp;amp; Gen Med"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neurocutaneous melanosis (NCM) is a rare congenital syndrome characterized by congenital melanocytic nevus of the skin with melanocytic deposits in the central nervous system. Patients with neurological symptoms have a poor prognosis and may die within years of symptom onset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Report<\/jats:title>\n                    <jats:p>A fetus was found to have diffuse enhancement of cerebellar hemispheric echo at 23\u2009weeks of gestation and amniocentesis was performed at 25\u2009weeks of gestation. Fetal DNA was extracted from amniotic fluid for copy number variation sequencing (CNV\u2010seq) and Trio\u2010total whole\u2010exome sequencing (Trio\u2010WES). However, genetic tests did not reveal pathogenic mutations associated with this case phenotype. At 29\u2009weeks of pregnancy, a fetoscopy examination was performed, and multiple scattered pigmentation spots were found on the skin of the fetus's back. At 31\u2009weeks of pregnancy, the pregnant woman requested an induced abortion to terminate the pregnancy. Multiple areas of pigmentation can be seen on the skin of a stillborn fetus. Pathological examination confirmed a large amount of melanin deposition in the cerebellum tissue of the stillborn fetus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      We reported a rare case of prenatal NCM, but no known pathogenic mutations, such as\n                      <jats:italic>NRAS<\/jats:italic>\n                      gene mutations, were found. This confirmed that there might be no definite pathogenic mutations in the NCM case, providing important data support for the prenatal identification and diagnosis of NCM.\n                    <\/jats:p>\n                    <jats:p>We reported a rare case of prenatal NCM, but no known pathogenic mutations, such as NARS gene mutations, were found. This confirmed that there might be no definite pathogenic mutations in the NCM case, providing important data support for the prenatal identification and diagnosis of NCM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mgg3.70174","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T17:31:21Z","timestamp":1767202281000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prenatal Fetal Neurocutaneous Melanosis: A Case Report and Literature Review"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4171-8967","authenticated-orcid":false,"given":"Xue","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University International Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University International Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University International Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiwen","family":"He","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University International Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology Peking University International Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University International Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University International Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University International Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1579628"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nov184"},{"issue":"4","key":"e_1_2_8_4_1","first-page":"382","article-title":"Neurocutaneous Melanosis","volume":"103","author":"Caldarelli M.","year":"2005","journal-title":"Journal of Neurosurgery"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.429"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1722676"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3941\/jrcr.v9i3.2141"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700366"},{"key":"e_1_2_8_9_1","first-page":"111","volume-title":"Handbook of Clinical Neurology","author":"Islam M. 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