{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T20:44:06Z","timestamp":1769287446142,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160501"],"award-info":[{"award-number":["82160501"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060460"],"award-info":[{"award-number":["82060460"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp;amp; Gen Med"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Nephrolithiasis is a common urological disorder and has become a significant global public health issue. Aldehyde dehydrogenase 2 (ALDH2), an important endogenous antioxidant enzyme involved in alcohol metabolism, has been shown to exert protective effects in various diseases. However, the specific role of\n                      <jats:italic>ALDH2<\/jats:italic>\n                      gene polymorphisms in kidney stone formation, particularly in relation to alcohol consumption, remains poorly understood.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this study, 979 nephrolithiasis patients and 1,009 healthy controls, matched for sex, age, and ethnicity, were enrolled. Genotyping of single nucleotide polymorphisms (SNPs) was performed, and a nephrolithiasis mouse model with\n                      <jats:italic>Aldh2<\/jats:italic>\n                      deficiency was established to assess the susceptibility to kidney stone formation under\n                      <jats:italic>Aldh2<\/jats:italic>\n                      \u2010deficient conditions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:italic>ALDH2<\/jats:italic>\n                      rs671 polymorphism and three nearby SNPs (rs3782886, rs4766566, and rs2188380) were significantly associated with nephrolithiasis. Moreover, in the ethylene glycol (EG)\u2010induced nephrolithiasis model, pathological examination of kidney sections from\n                      <jats:italic>Aldh2<\/jats:italic>\n                      knockout mice exposed to alcohol revealed a significantly higher calcium oxalate crystal deposition score, accompanied by elevated levels of 4\u2010hydroxy\u20102\u2010nonenal (4\u2010HNE) and malondialdehyde (MDA), compared with that in wild\u2010type mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ALDH2 deficiency was significantly associated with an increased risk of nephrolithiasis, and this risk was further exacerbated by alcohol consumption. These findings enhance our understanding of the role of ALDH2 in kidney stone pathogenesis and may inform the development of novel strategies for the prevention and treatment of nephrolithiasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mgg3.70175","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T08:05:24Z","timestamp":1767081924000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aldehyde Dehydrogenase 2 Gene Polymorphism and Alcohol Consumption Are Associated With Nephrolithiasis in a Chinese Population"],"prefix":"10.1002","volume":"14","author":[{"given":"Tao","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Urology The First Affiliated Hospital of Guangxi Medical University  Nanning Guangxi China"},{"name":"Center for Genomic and Personalized Medicine Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Medical 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