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A vast majority of the\n                      <jats:italic>de novo<\/jats:italic>\n                      variants were missense\/indel and classified as variants of uncertain significance. The\n                      <jats:italic>de novo<\/jats:italic>\n                      variants preferentially hit the intolerant genes and impacted the functional pathways such as Pol II transcription, heart development, and p53 signaling. In search of recessive variants associated with embryo lethality, six autosomal and four X\u2010chromosomal genes, which are functionally clustered into the pathways such as cilium assembly and regulation of cell morphogenesis, were prioritized for 12 family trios. Of the recessive variants, a large majority were missense and of uncertain significance. Notably, there were miscarriages having inherited biallelic variants and coincidental\n                      <jats:italic>de novo<\/jats:italic>\n                      variants. In perspective of maternal effect genes, homozygous or compound heterozygous missense variants of the\n                      <jats:italic>MEI4<\/jats:italic>\n                      gene were identified.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings reveal a significant heterogeneity and complexity in exomic variants contributing to RPL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mgg3.70220","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T07:31:07Z","timestamp":1776756667000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Genetic Landscape of Euploid Miscarriages From Couples With Recurrent Pregnancy Loss Through Whole Exome 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