{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T15:02:26Z","timestamp":1785078146433,"version":"3.55.0"},"reference-count":62,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp; Gen Med"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Alport syndrome (AS) is a multisystem hereditary disorder characterized by persistent hematuria, progressive renal insufficiency, sensorineural hearing loss, and ocular abnormalities. Its pathogenesis is mainly due to mutations in\n                      <jats:italic>COL4A3<\/jats:italic>\n                      ,\n                      <jats:italic>COL4A4<\/jats:italic>\n                      , or\n                      <jats:italic>COL4A5<\/jats:italic>\n                      genes encoding type IV collagen \u03b1 chains, leading to glomerular dysfunction and end\u2010stage renal disease. A systematic evaluation of its global research landscape is lacking, and bibliometric analysis can fill this gap.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive bibliometric analysis was conducted using Biblioshiny, VOSviewer, and CiteSpace. Data were extracted from the Web of Science Core Collection (2000\u20132025), with 1205 valid publications included. Multiple dimensions including annual output, citations, co\u2010authorship, and keywords were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Bibliometric analysis showed that AS\u2010related annual publications had a consistent upward trend from 2000 to 2025. The 1205 included publications accumulated 34,314 citations, with the most cited being R. C. Wiggins' 2007 original study (622 citations). Co\u2010authorship analysis identified Judy Savige as the most prolific author and the United States as the leading contributing country. Co\u2010citation analysis mapped the field's intellectual structure, and keywords included \u201cnatural history,\u201d \u201cIV collagen,\u201d and \u201cidentification\u201d besides core terms \u201cAlport syndrome\u201d and \u201cmutations\u201d.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Global interest in AS research has increased significantly. With academic exchanges and international cooperation, its pathogenesis mechanisms are gradually clarified. This bibliometric analysis identifies research hotspots and guides future directions, providing references for related research and clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mgg3.70272","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T04:20:28Z","timestamp":1784262028000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Knowledge Mapping of Alport Syndrome: A Bibliometric Analysis From 2000 to 2025"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0687-8278","authenticated-orcid":false,"given":"Xiujuan","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Nephrology, The Children's Hospital Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center  Hangzhou Zhejiang China"},{"name":"Department of Pediatrics 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