{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:05:12Z","timestamp":1790168712792,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"publisher","award":["T32NR009759"],"award-info":[{"award-number":["T32NR009759"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA196762"],"award-info":[{"award-number":["R01CA196762"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA221882"],"award-info":[{"award-number":["R01CA221882"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen & Gen Med"],"published-print":{"date-parts":[[2026,9]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Cognitive decline is common among individuals with breast cancer (BC), and carriage of the apolipoprotein E (APOE) \u03b54 allele increases risk.\n APOE<\/jats:italic>\n DNA methylation (DNAm) may influence cognition through regulation of neuroinflammatory and amyloid\u2010related pathways. Exercise is a potential factor affecting DNAm and cognition. This study examined associations between\n APOE<\/jats:italic>\n DNAm and cognition in postmenopausal women with BC and evaluated moderation by\n APOE4<\/jats:italic>\n carriage status and exercise.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Data were drawn from a 6\u2010month randomized trial of moderate\u2010intensity exercise versus usual care. Cognition was assessed at baseline and 6\u2009months, and change scores were calculated.\n APOE4<\/jats:italic>\n status (carrier, non\u2010carrier) and baseline DNAm (M\u2010value) were determined from peripheral blood. Regression models tested cross\u2010sectional and longitudinal associations, adjusting for age and education. Moderation by\n APOE4<\/jats:italic>\n status and intervention group was also tested.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 102 participants,\n APOE<\/jats:italic>\n DNAm was consistently suggestively associated with cognition. Higher DNAm at promoter\u2010region CpGs (cg04406254, cg14123992, cg20051876) was linked to poorer cognition, with direction and magnitude differing by\n APOE4<\/jats:italic>\n status and group.\n APOE4<\/jats:italic>\n carriers with higher DNAm showed better cognitive performance, and exercisers with higher DNAm showed improved outcomes, suggesting exercise may buffer epigenetic effects.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Findings may implicate\n APOE<\/jats:italic>\n DNAm as a biomarker of cognition and highlight exercise supporting cognitive health in women with BC, although replication is needed.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/mgg3.70302","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:17:31Z","timestamp":1789539451000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Apolipoprotein E DNA Methylation Linked to Cognitive Decline in Postmenopausal Women With Breast Cancer"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7830-8756","authenticated-orcid":false,"given":"Emily K.","family":"Mewborn","sequence":"first","affiliation":[{"name":"School of Nursing, Department of Health Promotion and Development University of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7690-5485","authenticated-orcid":false,"given":"Lacey W.","family":"Heinsberg","sequence":"additional","affiliation":[{"name":"School of Nursing, Department of Health Promotion and Development University of Pittsburgh Pittsburgh Pennsylvania USA"},{"name":"School of Public Health, Department of Human Genetics University of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2848-2200","authenticated-orcid":false,"given":"Myeong\u2010ga","family":"Cho","sequence":"additional","affiliation":[{"name":"School of Nursing, Department of Health Promotion and Development University of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8736-981X","authenticated-orcid":false,"given":"Kirk I.","family":"Erickson","sequence":"additional","affiliation":[{"name":"AdventHealth Research Institute, Neuroscience Institute Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1205-9950","authenticated-orcid":false,"given":"Catherine M.","family":"Bender","sequence":"additional","affiliation":[{"name":"School of Nursing, Department of Health Promotion and Development University of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvette P.","family":"Conley","sequence":"additional","affiliation":[{"name":"School of Nursing, Department of Health Promotion and Development University of Pittsburgh Pittsburgh Pennsylvania USA"},{"name":"School of Public Health, Department of Human Genetics University of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-022-01267-z"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.43.0116"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1891\/1061\u20103749.21.2.320"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.6298"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201600178"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.2258"},{"key":"e_1_2_12_8_1","volume-title":"Digital Cognitive Assessments","author":"Cambridge Cognition","year":"2023"},{"key":"e_1_2_12_9_1","first-page":"95","volume-title":"Psychology","author":"Chelune 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