{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:52:40Z","timestamp":1772959960124,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T00:00:00Z","timestamp":1558569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"crossref","award":["SZSM201612021"],"award-info":[{"award-number":["SZSM201612021"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Special Fundation for Science and Technology Development of Guangdong Province","award":["2017B090904010"],"award-info":[{"award-number":["2017B090904010"]}]},{"name":"Scientific Research Project of Health and Family Planning Commission of Shenzhen Municipality","award":["SZXJ2018086"],"award-info":[{"award-number":["SZXJ2018086"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp; Gen Med"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>ACYP2<\/jats:italic> gene may be involved in the process of telomere shortening which may be involved in the liver cancer. So, this research was to examine whether the <jats:italic>ACYP2<\/jats:italic> gene polymorphism has impact on the risk of liver cancer in Chinese population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred and fifty cirrhosis patients and 248 liver cancer patients were selected. Unconditional logistic regression was to calculate the odds ratio (OR) and 95% confidence intervals (CIs). Analyze the relationship between ACYP2 gene polymorphism and tumor using meta\u2010analysis. Analyze the expression of ACYP2 gene in liver cancer and its influence on the prognosis of liver cancer by databases (Ualcan, GTEX and Kaplan\u2013Meier plotter).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the allele model, <jats:italic>ACYP2<\/jats:italic> rs843720 was protection against the occurrence of cirrhosis developed into liver cancer (OR\u00a0=\u00a00.76, 95% CI: 0.58\u20130.99, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.04). Rs1682111 and rs843720 play a protective role in the additive model (rs1682111: OR\u00a0=\u00a00.69, 95% CI: 0.52\u20130.93, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.01; rs843720: OR\u00a0=\u00a00.73, 95% CI: 0.54\u20130.98, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.04).While rs843645 G allele increased the risk of cirrhosis developed into liver cancer under the additive model (OR\u00a0=\u00a01.42, 95% CI: 1.02\u20132.00, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.04).The haplotype analysis detected that \u201cATATCGCC\u201d decreased the risk of cirrhosis developed into liver cancer (OR\u00a0=\u00a00.69, 95% CI: 0.51\u20130.92, 95% CI: <jats:italic>p<\/jats:italic>\u00a0=\u00a00.013); however, \u201cTGAGCGTC\u201d increased the risk of cirrhosis developed into liver cancer (OR\u00a0=\u00a01.48, 95% CI: 1.04\u20132.10, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.027). Meta\u2010analysis shown that <jats:italic>ACYP2<\/jats:italic> rs1682111 was associated with the risk of cancer (OR\u00a0=\u00a00.90, 95% CI: 0.78\u20131.05, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.02). ACYP2 gene high expression was found to be associated with better OS for all liver patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Based on this research, we surmised that <jats:italic>ACYP2<\/jats:italic> gene may be involved in the occurrence of liver cancer in Chinese populations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.716","type":"journal-article","created":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T04:11:15Z","timestamp":1558671075000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Associations between polymorphisms of the <i>ACYP2<\/i> gene and Liver cancer risk: A case\u2010control study and meta\u2010analysis"],"prefix":"10.1002","volume":"7","author":[{"given":"Wenhui","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Shaanxi Provincial Cancer Hospital Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Liu","sequence":"additional","affiliation":[{"name":"Hepato\u2010Pancreato\u2010Biliary Surgery Peking University Shenzhen Hospital Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhendong","family":"Yu","sequence":"additional","affiliation":[{"name":"Central Laboratory Peking University Shenzhen Hospital Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zichao","family":"Xiong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University) Ministry of Education, Northwest University Xi\u2019an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiamin","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University) Ministry of Education, Northwest University Xi\u2019an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University) Ministry of Education, Northwest University Xi\u2019an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanglin","family":"Niu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University) Ministry of Education, Northwest University Xi\u2019an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6188-1345","authenticated-orcid":false,"given":"Jikui","family":"Liu","sequence":"additional","affiliation":[{"name":"Hepato\u2010Pancreato\u2010Biliary Surgery Peking University Shenzhen Hospital Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianbo","family":"Jin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University) Ministry of Education, Northwest University Xi\u2019an China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,23]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"613","article-title":"Example of the use of the nonparametric test. 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