{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:51:37Z","timestamp":1762005097504,"version":"3.41.2"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T00:00:00Z","timestamp":1558310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010679","name":"Pasteur Institute of Iran","doi-asserted-by":"publisher","award":["1033"],"award-info":[{"award-number":["1033"]}],"id":[{"id":"10.13039\/501100010679","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp; Gen Med"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Glutathione S\u2010transferases (GSTs) polymorphisms may impact on chronic myeloid leukemia (CML) risk or heterogeneous responses to Imatinib mesylate (IM). The aim of this study was to evaluate the correlation between GSTs polymorphisms and CML risk, treatment response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We genotyped GSTM1, GSTT1 null deletion polymorphisms, and GSTP1 Ile105Val polymorphism by PCR methods and BCR\u2010ABL transcripts were analyzed by qRT\u2010PCR in 104 CML patients and 104 sex\u2010 and age\u2010matched healthy individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Individual analysis showed significant association of GSTM1 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.008; OR\u00a0=\u00a00.46; 95% CI: 0.26\u20130.82) and GSTP1 genes (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.04; OR\u00a0=\u00a01.56; 95% CI: 1.016\u20132.423) with CML risk. The combined analysis indicated that GSTM1 null\/GSTT1 present, GSTM1\u2010null\/GSTP1M*(AG\/GG) as well as GSTT1 present\/ GSTP1M* genotype were associated with CML risk (ORg(\u2010):2.28; 95% CI: 1.29\u20134.04; ORgg: 2.85; 95% CI: 1.36\u20135.97; OR(\u2010)g: 1.75; 95% CI: 0.99\u20133.06, respectively). The proportion of CML cancer attributable to the interaction of smoking and GSTM1 null, GSTT1null, and GSTP1 M* was 42%, 39%, and 13%, respectively. Patients with GSTM1\u2010null and GSTP1 AG\/GG genotype had significantly a lower rate of MMR achievement (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.00; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.009 respectively). Event\u2010free survival (EFS) percentage was similar between GSTM1 null and GSTM1 present patients (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.21).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study suggests the influence of GSTM1 and GSTP1 polymorphisms on CML risk and treatment response. The interaction between GSTs polymorphisms and smoking plays a significant role on CML susceptibility.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.717","type":"journal-article","created":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T00:34:26Z","timestamp":1558398866000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Influence of glutathione S\u2010transferases (GSTM1, GSTT1, and GSTP1) genetic polymorphisms and smoking on susceptibility risk of chronic myeloid leukemia and treatment response"],"prefix":"10.1002","volume":"7","author":[{"given":"Golale","family":"Rostami","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine, Biotechnology Research Center Pasteur Institute of Iran Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dlnya","family":"Assad","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science Sulaimani University Sulaymanyah Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Ghadyani","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular, Faculty of Biology Sciences Islamic azad university of Tehran North Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4625-0713","authenticated-orcid":false,"given":"Mohammad","family":"Hamid","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Biotechnology Research Center Pasteur Institute of Iran Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amirhossien","family":"Karami","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Biotechnology Research Center Pasteur Institute of Iran Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan","family":"Jalaeikhoo","sequence":"additional","affiliation":[{"name":"AJA Cancer Epidemiology Research and Treatment Center (AJA\u2010 CERTC) AJA University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramezan Ali","family":"Kalahroodi","sequence":"additional","affiliation":[{"name":"AJA Cancer Research Center (ACRC) AJA University of Medical Science Tehran 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