{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T01:20:39Z","timestamp":1768353639597,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T00:00:00Z","timestamp":1560470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp; Gen Med"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Polycystic kidney disease (PKD) is an inherited condition characterized by progressive development of end\u2010stage renal disease, hypertension, hepatic fibrosis, and cysts in the kidney, liver, pancreas, spleen, thyroid, and epididymis. While malignancies have been reported in association with PKD in adults, the incidence of malignancies in children with PKD is not currently known.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We report on five patients with a known history of PKD who developed a malignancy as children at the University of California, Los Angeles and the University of Colorado Anschutz Medical Campus. Patients were included from 2012 to 2017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We present five patients with a history of PKD diagnosed with a malignancy during childhood without any additional known mutations to suggest a genetic predisposition to develop cancer. This includes the first reported case of hepatocellular carcinoma in a patient with autosomal recessive polycystic kidney disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our report illustrates the potential that PKD may be associated with an increased risk for developing cancer, even in children. Further research is necessary to better understand this relationship.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.725","type":"journal-article","created":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T07:30:36Z","timestamp":1560497436000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Is polycystic kidney disease associated with malignancy in children?"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8652-4400","authenticated-orcid":false,"given":"Brian D.","family":"Friend","sequence":"first","affiliation":[{"name":"Department of Pediatrics UCLA Mattel Children's Hospital Los Angeles California"},{"name":"Department of Pediatrics UCSF Benioff Children's Hospital San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kami","family":"Wolfe Schneider","sequence":"additional","affiliation":[{"name":"Section of Hematology, Oncology, and Bone Marrow Transplantation University of Colorado Anschutz Medical Campus, Children's Hospital Colorado Aurora Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Garrington","sequence":"additional","affiliation":[{"name":"Section of Hematology, Oncology, and Bone Marrow Transplantation University of Colorado Anschutz Medical Campus, Children's Hospital Colorado Aurora Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurel","family":"Truscott","sequence":"additional","affiliation":[{"name":"Department of Pediatrics UCLA Mattel Children's Hospital Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6776-6949","authenticated-orcid":false,"given":"Julian A.","family":"Martinez\u2010Agosto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics UCLA Mattel Children's Hospital Los Angeles California"},{"name":"Department of Human Genetics UCLA David Geffen School of Medicine Los Angeles California"},{"name":"UCLA Clinical Genomics Center Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert S.","family":"Venick","sequence":"additional","affiliation":[{"name":"Department of Pediatrics UCLA Mattel Children's Hospital Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen","family":"Tsai Chambers","sequence":"additional","affiliation":[{"name":"Department of Pediatrics UCLA Mattel Children's Hospital Los Angeles California"},{"name":"Division of Pediatric Nephrology, Department of Pediatrics Duke University Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics UCLA Mattel Children's Hospital Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas G.","family":"Farmer","sequence":"additional","affiliation":[{"name":"Department of Surgery UCLA David Geffen School of Medicine Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivian Y.","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics UCLA Mattel Children's Hospital Los Angeles California"},{"name":"UCLA's Jonsson Comprehensive Cancer Center Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noah","family":"Federman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics UCLA Mattel Children's Hospital Los Angeles California"},{"name":"UCLA's Jonsson Comprehensive Cancer Center Los Angeles California"},{"name":"Department of Orthopaedics UCLA David Geffen School of Medicine Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02020309"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201006173"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-017-0683-1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27800"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2016.01.006"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/16.8.1648"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29140"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2004.12.021"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-3646"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000351049"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(03)00004-5"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-013-2657-7"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000422"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2011.05.001"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1538\/expanim.61.477"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr467"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-016-3364-y"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2014-207471"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2012.00028"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2015.46"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0509694103"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0190430"},{"key":"e_1_2_7_24_1","volume-title":"SEER Cancer Statistics Review, 1975\u20102015. Table 28.1","author":"Surveillance, Epidemiology, and End Results Program","year":"2018"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-011-2026-2"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26197"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013101122"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30250-9"}],"container-title":["Molecular Genetics &amp; Genomic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmgg3.725","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mgg3.725","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mgg3.725","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mgg3.725","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T05:02:04Z","timestamp":1694322124000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mgg3.725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,14]]},"references-count":27,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1002\/mgg3.725"],"URL":"https:\/\/doi.org\/10.1002\/mgg3.725","archive":["Portico"],"relation":{},"ISSN":["2324-9269","2324-9269"],"issn-type":[{"value":"2324-9269","type":"print"},{"value":"2324-9269","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,14]]},"assertion":[{"value":"2018-11-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00725"}}