{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:47:57Z","timestamp":1761598077417,"version":"3.41.2"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T00:00:00Z","timestamp":1558569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81460332"],"award-info":[{"award-number":["81460332"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp; Gen Med"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ankylosing spondylitis (AS) is the second most common cause of inflammatory arthritis worldwide affecting the axial skeleton. Single nucleotide polymorphisms (SNPs) of matrix metalloproteinase\u20103 (MMP3) in the development of AS has few been investigated in Chinese population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 362 patients with AS and 362 healthy controls were enrolled in the study. Five SNPs in MMP3 genotypes were identified by Agena MassARRAY. Chi\u2010squared tests and genetic model were used to evaluate associations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>rs522616 had a significant risk of AS development compared to those with the TT genotype (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.008). By multiple logistic regression models analysis, in codominant model, rs522616 CT genotypes also had a 1.44\u2010fold risk (95% CI\u00a0=\u00a01.06\u20131.96, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.008) for AS development compared to those with TT genotypes. In recessive model, the CC genotypes was a significantly reduced AS risk for individuals with TT\/CT genotype (OR\u00a0=\u00a00.64; 95% CI\u00a0=\u00a00.41\u20130.99, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.040).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present study suggests that MMP3 rs522616 polymorphism is associated with AS susceptibility and MMP3 might be a potential diagnostic biomarker for AS. Further independent studies with larger cohorts are warranted to validate our findings in different populations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.752","type":"journal-article","created":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T04:10:04Z","timestamp":1558671004000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Association study between matrix metalloproteinase\u20103 gene (MMP3) polymorphisms and ankylosing spondylitis susceptibility"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8840-686X","authenticated-orcid":false,"given":"Yong","family":"Zhu","sequence":"first","affiliation":[{"name":"The Second Affiliated Hospital of Inner Mongolia Medical University Hohhot China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunan","family":"Li","sequence":"additional","affiliation":[{"name":"The Hohhot First Hospital Hohhot China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi","family":"Huang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Inner Mongolia Medical University Hohhot China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhua","family":"Xing","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Inner Mongolia Medical University Hohhot China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Li","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Inner Mongolia Medical University Hohhot China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifeng","family":"Da","sequence":"additional","affiliation":[{"name":"Inner Mongolia Medical University Hohhot China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianmin","family":"Xue","sequence":"additional","affiliation":[{"name":"Inner Mongolia Medical University Hohhot China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manglai","family":"Li","sequence":"additional","affiliation":[{"name":"Inner Mongolia Medical University Hohhot China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Sun","sequence":"additional","affiliation":[{"name":"Inner Mongolia Medical University Hohhot China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyu","family":"Jia","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Inner Mongolia Medical University Hohhot China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2713-7237","authenticated-orcid":false,"given":"Xuejun","family":"Yang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Inner Mongolia Medical University Hohhot China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390919"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth457"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7247.1468"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1609622"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kei208"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471142905.hg0212s60"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/36.7.744"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.54.1.25"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.25.14657"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh429"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s000180050495"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-6-270"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.4172\/2155-9899.1000422"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-9525(90)90126-Q"},{"key":"e_1_2_7_16_1","first-page":"151","article-title":"Activation mechanisms of matrix metalloproteinases","volume":"378","author":"Nagase H.","year":"1997","journal-title":"Biological Chemistry"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2005.12.002"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.48.8.645"},{"issue":"1","key":"e_1_2_7_19_1","first-page":"2","article-title":"The genetics of ankylosing spondylitis","volume":"50","author":"Reveille J. 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