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Antihypertensive treatment reduces LV mass (LVM). However, interindividual variation in LV traits in response to antihypertensive treatments exists. We hypothesized that genetic variants may modify the association of antihypertensive treatment class with LV traits measured by echocardiography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated the main effects of the three most common antihypertensive treatments for AAs as well as the single nucleotide polymorphism (SNP)\u2010by\u2010drug interaction on LVM and relative wall thickness (RWT) in 2,068 participants across five community\u2010based cohorts. Treatments included thiazide diuretics (TDs), angiotensin converting enzyme inhibitors (ACE\u2010Is), and dihydropyridine calcium channel blockers (dCCBs) and were compared in a pairwise manner. We performed fixed effects inverse variance weighted meta\u2010analyses of main effects of drugs and 2.5\u00a0million SNP\u2010by\u2010drug interaction estimates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed that dCCBs versus TDs were associated with higher LVM after adjusting for covariates (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001). We report three SNPs at a single locus on chromosome 20 that modified the association between RWT and treatment when comparing dCCBs to ACE\u2010Is with consistent effects across cohorts (smallest <jats:italic>p<\/jats:italic>\u00a0=\u00a04.7\u00a0\u00d7\u00a010<jats:sup>\u22128<\/jats:sup>, minor allele frequency range 0.09\u20130.12). This locus has been linked to LV hypertrophy in a previous study. A marginally significant locus in <jats:italic>BICD1<\/jats:italic> (rs326641) was validated in an external population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study identified one locus having genome\u2010wide significant SNP\u2010by\u2010drug interaction effect on RWT among dCCB users in comparison to ACE\u2010I users. Upon additional validation in future studies, our findings can enhance the precision of medical approaches in hypertension treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.788","type":"journal-article","created":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T08:39:28Z","timestamp":1565685568000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Genome\u2010wide meta\u2010analysis of SNP and antihypertensive medication interactions on left ventricular traits in African Americans"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3316-9887","authenticated-orcid":false,"given":"Anh N.","family":"Do","sequence":"first","affiliation":[{"name":"Department of Epidemiology University of Alabama at Birmingham Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of 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