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However, given the low resolution of CMA at this homologous locus, it was unclear if the neighboring <jats:italic>STRC<\/jats:italic> hearing loss gene was also affected. Therefore, we developed a novel allele\u2010specific PCR strategy, which narrowed the proximal breakpoint of the maternally inherited deletion to a 310 bp interval that was 440 bp upstream from the <jats:italic>STRC<\/jats:italic> transcription start site.<\/jats:p>","DOI":"10.1002\/mgg3.806","type":"journal-article","created":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T02:18:16Z","timestamp":1560997096000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prenatal cytogenomic identification and molecular refinement of compound heterozygous <i>STRC<\/i> deletion breakpoints"],"prefix":"10.1002","volume":"7","author":[{"given":"Lisong","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York City New York"},{"name":"Sema4, a Mount Sinai Venture Stamford Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York City New York"},{"name":"Sema4, a Mount Sinai Venture Stamford Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yara","family":"Kharbutli","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York City New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea M.","family":"Oza","sequence":"additional","affiliation":[{"name":"Laboratory for Molecular Medicine Partners Personalized Medicine Cambridge Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sami S.","family":"Amr","sequence":"additional","affiliation":[{"name":"Laboratory for Molecular Medicine Partners Personalized Medicine Cambridge Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Edelmann","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York City New York"},{"name":"Sema4, a Mount Sinai Venture Stamford Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lakshmi","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York City New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5720-1864","authenticated-orcid":false,"given":"Stuart A.","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York City New York"},{"name":"Sema4, a Mount Sinai Venture Stamford Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,19]]},"reference":[{"key":"e_1_2_1_6_2_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2017.280685"},{"key":"e_1_2_1_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200991"},{"key":"e_1_2_1_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16846-9"},{"key":"e_1_2_1_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.34391"},{"key":"e_1_2_1_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1755-8166-6-19"},{"key":"e_1_2_1_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.38154"},{"key":"e_1_2_1_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2008.063685"},{"key":"e_1_2_1_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2014.06.003"},{"key":"e_1_2_1_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2016.58"},{"key":"e_1_2_1_6_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/gtmb.2017.0155"},{"key":"e_1_2_1_6_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/gm554"},{"key":"e_1_2_1_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-016-1648-8"},{"key":"e_1_2_1_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12332"},{"key":"e_1_2_1_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2016.182"},{"key":"e_1_2_1_6_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2006.045765"}],"container-title":["Molecular Genetics &amp; 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