{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:02:10Z","timestamp":1753869730374,"version":"3.41.2"},"reference-count":13,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T00:00:00Z","timestamp":1560816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp; Gen Med"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Congenital hypothyroidism in infants is the cause of mental retardation in children, it can be detected in patient and treated at a relatively cheap rate, preventing patient retard. This study aimed to determine the prevalence of congenital hypothyroidism among Khorramabad children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the present study, we identified all patients who had received levothyroxine prescriptions during the study period (2007\u20132017). Using this as a congenital hypothyroidism surrogate marker, we considered the congenital hypothyroidism prevalence in children above 3\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 574 patients who had received levothyroxine during the neonatal period up to 3\u00a0years, the results of one\u2010variable logistic regression analysis showed that the chance of temporary disease in children with small thyroid ultrasonography was 62% less, than for those without problems, and this difference was significant. The chance of temporary disease in children who had other cases was 87% less than those without problems, and this difference was statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The overall prevalence of congenital hypothyroidism in young patients up to 3\u00a0years is 0.143%, these values are at least twice those of previous estimates. This proposes an elevation in autoimmune thyroid disease, which is similitude to the rising prevalence of diabetes type 1, which possibly indicates a rising incidence of autoimmunity in youth.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.817","type":"journal-article","created":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T09:26:47Z","timestamp":1560936407000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A 10\u2010year prevalence of congenital hypothyroidism in Khorramabad (Urban Western Iran)"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6046-6342","authenticated-orcid":false,"given":"Nadereh","family":"Taee","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Lorestan University of Medical Sciences Khorramabad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7494-2557","authenticated-orcid":false,"given":"Mojgan","family":"Faraji Goodarzi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Lorestan University of Medical Sciences Khorramabad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Safdari","sequence":"additional","affiliation":[{"name":"Student Research Committee Lorestan University of Medical Sciences Khorramabad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Bajelan","sequence":"additional","affiliation":[{"name":"Student Research Committee Lorestan University of Medical Sciences Khorramabad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,18]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"752","article-title":"Congenital hypothyroidism: Etiology and growth\u2010development outcome","volume":"52","author":"Dalili S.","year":"2014","journal-title":"Acta Medica Iranica"},{"issue":"2","key":"e_1_2_6_3_1","first-page":"84","article-title":"Cost\u2010benefit analysis of the neonatal screening program implementation for congenital hypothyroidism in IR Iran","volume":"4","author":"Delavari A.","year":"2006","journal-title":"International Journal of Endocrinology and Metabolism"},{"issue":"2","key":"e_1_2_6_4_1","first-page":"38","article-title":"Iron\u2010deficiency anemia in children with febrile seizure: A case\u2010control study","volume":"8","author":"Ghasemi F.","year":"2014","journal-title":"Iranian Journal of Child Neurology"},{"issue":"8","key":"e_1_2_6_5_1","first-page":"699","article-title":"Prevalence of transient congenital hypothyroidism in central part of Iran","volume":"18","author":"Ghasemi M.","year":"2013","journal-title":"Journal of Research in Medical Sciences"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2010.190280"},{"key":"e_1_2_6_7_1","unstructured":"M. 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