{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:02:28Z","timestamp":1767650548440,"version":"3.41.2"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T00:00:00Z","timestamp":1560729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81160228","81260284","81660378"],"award-info":[{"award-number":["81160228","81260284","81660378"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp; Gen Med"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Alcohol\u2010induced osteonecrosis of femoral head (ONFH) is a complex disease and genetic factors are one of the causes. The purpose of this study is to investigate the effects of <jats:italic>RETN<\/jats:italic> (resistin; OMIM: 605565) and <jats:italic>LDLR<\/jats:italic> (low density lipoprotein receptor; OMIM: 606945) polymorphisms on the risk of alcohol\u2010induced ONFH in Chinese Han population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A case\u2013control study including 201 patients and 201 controls was designed. Seven single nucleotide polymorphisms (SNPs) in <jats:italic>RETN<\/jats:italic> gene and four SNPs in <jats:italic>LDLR<\/jats:italic> gene were genotyped using Agena MassARRAY platform. In allele model and genetic model, chi\u2010square test and logistic regression were used to study the associations between these SNPs and ONFH susceptibility. In addition, the relationships between these SNPs, clinical phenotypes, and blood lipid level with one\u2010way analysis of variance were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the allele model, rs7408174 and rs3745369 in <jats:italic>RETN<\/jats:italic> were associated with increased risk of alcohol\u2010induced ONFH, whereas rs34861192 and rs3219175 in <jats:italic>RETN<\/jats:italic> showed reduced risk of alcohol\u2010induced ONFH. In the genetic model, rs7408174 was associated with increased risk of alcohol\u2010induced ONFH in dominant model and log\u2010additive model. Rs3745369 showed an increased risk in codominant model, recessive model, and log\u2010additive model. Rs34861192 showed a decreased risk in codominant model, dominant model, and log\u2010additive model, and rs3219175 showed a decreased risk in dominant model and log\u2010additive model. The rs3745368 in <jats:italic>RETN<\/jats:italic> was associated with the clinical stage of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results suggest that <jats:italic>RETN<\/jats:italic> genetic polymorphisms are associated with the susceptibility of alcohol\u2010induced ONFH in Chinese Han population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.822","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T17:40:25Z","timestamp":1560793225000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Significant association between <i>RETN<\/i> genetic polymorphisms and alcohol\u2010induced osteonecrosis of femoral head"],"prefix":"10.1002","volume":"7","author":[{"given":"Chang","family":"Liu","sequence":"first","affiliation":[{"name":"Inner Mongolia Medical University Hohhot China"},{"name":"Department of Orthopedics and Traumatology The Second Affiliated Hospital of Inner Mongolia Medical University Hohhot China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feimeng","family":"An","sequence":"additional","affiliation":[{"name":"Inner Mongolia Medical University Hohhot China"},{"name":"Department of Orthopedics and Traumatology The Second Affiliated Hospital of Inner Mongolia Medical University Hohhot China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuju","family":"Cao","sequence":"additional","affiliation":[{"name":"Zhengzhou Traditional Chinese Medicine (TCM) Traumatology Hospital Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqi","family":"Wang","sequence":"additional","affiliation":[{"name":"Inner Mongolia Medical University Hohhot China"},{"name":"Department of Orthopedics and Traumatology The Second Affiliated Hospital of Inner Mongolia Medical University Hohhot China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Tian","sequence":"additional","affiliation":[{"name":"Inner Mongolia Medical University Hohhot China"},{"name":"Department of Orthopedics and Traumatology The Second Affiliated Hospital of Inner Mongolia Medical University Hohhot China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiqiang","family":"Wu","sequence":"additional","affiliation":[{"name":"Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine Hohhot China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0548-3665","authenticated-orcid":false,"given":"Jianzhong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology The Second Affiliated Hospital of Inner Mongolia Medical University Hohhot China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1517-2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-014-0229-1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13000"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-007-0395-2"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/03009742.2017.1314000"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejm198709173171204"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2016.11.005"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27635"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2015.00165"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-015-3763-9"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2005.02312.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-1936"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/rej.2013.1436"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.7473"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20915"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000010177"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-018-4172-8"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00013.2016"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3275\/688610.1007\/bf03346674"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2017.10.084"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574888X13666181025120252"}],"container-title":["Molecular Genetics &amp; 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