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Detected variants were annotated and filtered using ANNOVAR and FILTUS software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen variants were revealed in <jats:italic>MLH1<\/jats:italic>, <jats:italic>MSH2<\/jats:italic>, and <jats:italic>MSH6<\/jats:italic>, all genes previously linked to LS. Five additional genes (<jats:italic>EXO1<\/jats:italic>, <jats:italic>POLD1<\/jats:italic>, <jats:italic>RFC1<\/jats:italic>, <jats:italic>RPA1<\/jats:italic>, <jats:italic>and MLH3<\/jats:italic>) were found to harbor 11 variants of unknown significance in our sample cohort, two of them being frameshift variants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We have shown that other genes associated with the process of DNA MMR have a high probability of being associated with LLS families. These findings indicate that the spectrum of genes that should be tested when considering an entity like Lynch\u2010like syndrome should be expanded so that a more inclusive definition of this entity can be developed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.850","type":"journal-article","created":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T08:08:31Z","timestamp":1562918911000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Comprehensive mismatch repair gene panel identifies variants in patients with Lynch\u2010like syndrome"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6397-051X","authenticated-orcid":false,"given":"Alexandre","family":"Xavier","sequence":"first","affiliation":[{"name":"University of Newcastle Hunter Medical Research Institute New Lambton Heights New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maren Fridtjofsen","family":"Olsen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Department of Clinical and Molecular Medicine Norwegian University of Science and Technology Trondheim Norway"},{"name":"Department of Medical Genetics Saint Olavs Hospital University Hospital Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liss A.","family":"Lavik","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Saint Olavs Hospital University Hospital Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jostein","family":"Johansen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Department of Clinical and Molecular Medicine Norwegian University of Science and Technology Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashish Kumar","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Saint Olavs Hospital University Hospital Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenche","family":"Sjursen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Department of Clinical and Molecular Medicine Norwegian University of Science and Technology Trondheim Norway"},{"name":"Department of Medical Genetics Saint Olavs Hospital University Hospital Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodney J.","family":"Scott","sequence":"additional","affiliation":[{"name":"University of Newcastle Hunter Medical Research Institute New Lambton Heights New South Wales Australia"},{"name":"Pathology North Hunter New England Health Newcastle New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bente A.","family":"Talseth\u2010Palmer","sequence":"additional","affiliation":[{"name":"University of Newcastle Hunter Medical Research Institute New Lambton Heights New South Wales Australia"},{"name":"M\u00f8re and Romsdal Hospital Trust, Clinic Research and Development Molde Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2016.06.015"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/21.7.1855"},{"issue":"150","key":"e_1_2_7_4_1","first-page":"1","article-title":"Hereditary nonpolyposis colorectal cancer: Diagnostic strategies and their implications","author":"Bonis P. 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