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We believe that a strong understanding of where we are in our experimental understanding of the CLN3 gene, its regulation, gene product, protein structure, tissue distribution, biomarker use, and pathological responses to its deficiency, lays the groundwork for determining therapeutic action plans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To present an unbiased comprehensive reference tool of the experimental understanding of the CLN3 gene and gene product of the same name.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>BBDF compiled all of the available CLN3 gene and protein data from biological databases, repositories of federally and privately funded projects, patent and trademark offices, science and technology journals, industrial drug and pipeline reports as well as clinical trial reports and with painstaking precision, validated the information together with experts in Batten disease, lysosomal storage disease, lysosome\/endosome biology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The finished product is an indexed review of the CLN3 gene and protein which is not limited in page size or number of references, references all available primary experiments, and does not draw conclusions for the reader.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Revisiting the experimental history of a target gene and its product ensures that inaccuracies and contradictions come to light, long\u2010held beliefs and assumptions continue to be challenged, and information that was previously deemed inconsequential gets a second look. Compiling the information into one manuscript with all appropriate primary references provides quick clues to which studies have been completed under which conditions and what information has been reported. This compendium does not seek to replace original articles or subtopic reviews but provides an historical roadmap to completed works.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.859","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T05:33:34Z","timestamp":1569908014000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["The CLN3 gene and protein: What we know"],"prefix":"10.1002","volume":"7","author":[{"given":"Myriam","family":"Mirza","sequence":"first","affiliation":[{"name":"Mila\u2019s Miracle Foundation Boulder Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Vainshtein","sequence":"additional","affiliation":[{"name":"Craft Science Inc. 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