{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T16:15:24Z","timestamp":1782836124182,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T00:00:00Z","timestamp":1566950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"INBIOMEDIC"},{"name":"Universidad de Hu\u00e1nuco"},{"name":"UTEC"},{"name":"Gen Lab del Peru"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp;amp; Gen Med"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Guillain\u2013Barre Syndrome (GBS) is considered a complex disorder with significant environmental effect and genetic susceptibility. Genetic polymorphisms in\n                      <jats:italic>CD1E<\/jats:italic>\n                      ,\n                      <jats:italic>CD1A<\/jats:italic>\n                      ,\n                      <jats:italic>IL\u201017<\/jats:italic>\n                      , and\/or\n                      <jats:italic>ICAM1<\/jats:italic>\n                      had been proposed as susceptibility genetic variants for GBS mainly in Caucasian population. This study explores the association between selected polymorphisms in these genes and GBS susceptibility in confirmed GBS cases reported in mestizo population from northern Peru during the most recent GBS outbreak of May 2018.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of nine nonrelated cases and 11 controls were sequenced for the polymorphic regions of\n                      <jats:italic>CD1A<\/jats:italic>\n                      ,\n                      <jats:italic>CD1E<\/jats:italic>\n                      ,\n                      <jats:italic>IL\u201017<\/jats:italic>\n                      , and\n                      <jats:italic>ICAM1<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We found a significant protective association between heterozygous GA genotype in\n                      <jats:italic>ICAM1<\/jats:italic>\n                      (241Gly\/Arg) and GBS (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.047).\n                      <jats:italic>IL\u201017<\/jats:italic>\n                      was monomorphic in both controls and patients. No significant differences were found in the frequency of SNPs in\n                      <jats:italic>CD1A<\/jats:italic>\n                      and\n                      <jats:italic>CD1E<\/jats:italic>\n                      between the group with GBS patients and healthy controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      I\n                      <jats:italic>CAM1<\/jats:italic>\n                      polymorphisms might be considered as potential genetic markers of GBS susceptibility\n                      <jats:bold>.<\/jats:bold>\n                      Further studies with larger sample size will be required to validate these findings.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mgg3.960","type":"journal-article","created":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T21:11:34Z","timestamp":1567026694000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Guillain\u2013Barre syndrome outbreak in Peru: Association with polymorphisms in\n                    <i>IL\u201017<\/i>\n                    ,\n                    <i>ICAM1<\/i>\n                    , and\n                    <i>CD1<\/i>"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5093-6067","authenticated-orcid":false,"given":"Luis","family":"Jaramillo\u2010Valverde","sequence":"first","affiliation":[{"name":"INBIOMEDIC Research and Technological Center Lima Peru"},{"name":"ALBIOTEC Lima Peru"},{"name":"School of Public Health and Administration Universidad Peruana Cayetano Heredia Lima 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