{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T19:38:50Z","timestamp":1784230730990,"version":"3.55.0"},"reference-count":55,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T00:00:00Z","timestamp":1569974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013394","name":"Instituto Nacional de Medicina Gen\u00f3mica","doi-asserted-by":"publisher","award":["23\/2015\/I"],"award-info":[{"award-number":["23\/2015\/I"]}],"id":[{"id":"10.13039\/501100013394","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp;amp; Gen Med"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Evidence suggests that liability for suicide behavior is heritable; additionally, suicide has been partly related to other psychiatric disorders. Nevertheless, most of the information reported so far address Caucasian and Asian individuals. Hence, our aim was to conduct a gene\u2010level association study in Mexican psychiatric individuals diagnosed with suicide attempt.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited 192 individuals from two clinical centers in Mexico. All participants were born in Mexico and had Mexican parents and grandparents. Direct genotyping was performed using the commercial platform Infinium PsychArray BeadChip. A <jats:italic>p<\/jats:italic>\u2010value lower than 1e\u201005 was considered as gene\u2010level significant and a <jats:italic>p<\/jats:italic>\u2010value lower than 1e\u201004 was considered as gene\u2010level nominal significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our analyses showed that <jats:italic>SCARA5<\/jats:italic> was associated to suicide intent at a gene\u2010level with statistical significance (<jats:italic>p<\/jats:italic>\u2010value\u00a0=\u00a01.12e\u20106). Other genes were nominally associated with suicide attempt: <jats:italic>GHSR<\/jats:italic> (<jats:italic>p<\/jats:italic>\u2010value\u00a0=\u00a00.0004), <jats:italic>RGS10<\/jats:italic> (<jats:italic>p<\/jats:italic>\u2010value\u00a0=\u00a05.13e\u20105), and <jats:italic>STK33<\/jats:italic> (<jats:italic>p<\/jats:italic>\u2010value\u00a0=\u00a03.62e\u20105). Regarding gene variant analyses, the SNPs with a statistical association (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a0.05) were rs561361616, rs1537577, rs11198999 for <jats:italic>RGS10<\/jats:italic>, and rs11041981, rs11041993, rs11041994, rs11041995, rs11041997, rs10840083, rs10769918 for <jats:italic>STK33<\/jats:italic>. For these genes, previous studies have associated <jats:italic>SCARA5<\/jats:italic> with depression, <jats:italic>GHSR<\/jats:italic> with alcohol dependence and depression, and <jats:italic>RGS10<\/jats:italic> with schizophrenia and depression. To date, <jats:italic>STK33<\/jats:italic> has not been associated with any psychiatric disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our outcomes revealed that <jats:italic>SCARA5<\/jats:italic>, <jats:italic>GHSR<\/jats:italic>, <jats:italic>RGS10<\/jats:italic> and <jats:italic>STK33<\/jats:italic> could be considered as risk biomarkers for suicide attempt behavior in our Mexican psychiatric sample. We recommend to perform larger scale analyses to have conclusive results.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.983","type":"journal-article","created":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T03:18:28Z","timestamp":1570072708000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Gene\u2010level genome\u2010wide association analysis of suicide attempt, a preliminary study in a psychiatric Mexican population"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8046-6908","authenticated-orcid":false,"given":"Thelma Beatriz","family":"Gonz\u00e1lez\u2010Castro","sequence":"first","affiliation":[{"name":"Divisi\u00f3n Acad\u00e9mica Multidisciplinaria de Jalpa de M\u00e9ndez Universidad Ju\u00e1rez Aut\u00f3noma de Tabasco Mexico City Mexico"},{"name":"Divisi\u00f3n Acad\u00e9mica Multidisciplinaria de Ciencias de la Salud Universidad Ju\u00e1rez Aut\u00f3noma de Tabasco Villahermosa Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0390-8252","authenticated-orcid":false,"given":"Jos\u00e9 Jaime","family":"Mart\u00ednez\u2010Maga\u00f1a","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n Acad\u00e9mica Multidisciplinaria de Ciencias de la Salud Universidad Ju\u00e1rez Aut\u00f3noma de Tabasco Villahermosa Mexico"},{"name":"Instituto Nacional de Medicina Gen\u00f3mica (INMEGEN) Secretaria de Salud Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8170-8171","authenticated-orcid":false,"given":"Carlos Alfonso","family":"Tovilla\u2010Z\u00e1rate","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n Acad\u00e9mica Multidisciplinaria de Comalcalco Universidad Ju\u00e1rez Aut\u00f3noma de Tabasco Comalcalco Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isela Esther","family":"Ju\u00e1rez\u2010Rojop","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n Acad\u00e9mica Multidisciplinaria de Ciencias de la Salud Universidad Ju\u00e1rez Aut\u00f3noma de Tabasco Villahermosa Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Sarmiento","sequence":"additional","affiliation":[{"name":"Hospital Psiqui\u00e1trico Infantil \"Dr. Juan N. 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