{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:06:30Z","timestamp":1792098390447,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,5,5]],"date-time":"2003-05-05T00:00:00Z","timestamp":1052092800000},"content-version":"vor","delay-in-days":124,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microsurgery"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In order to further improve and explore the role of lasers for nerve reconstruction, this study was designed to investigate regeneration of sharply transected peripheral nerves repaired with a CO<jats:sub>2<\/jats:sub> milliwatt laser in combination with three different suture materials and a bovine albumin protein solder as an adjunct to the welding process. Unilateral sciatic nerve repair was performed in 44 rats. In the laser group, nerves were gently apposed, and two stay sutures (10\u20100 nylon, 10\u20100 polyglycolic acid, or 25\u2010\u03bcm stainless steel) were placed epi\/perineurially. Thereafter, the repair site was fused at 100 mW with pulses of 1.0 s. In the subgroup of laser\u2010assisted nerve repair (LANR), albumen was used as a soldering agent to further reinforce the repair site. The control group consisted of nerves repaired by conventional microsurgical suture repair (CMSR), using 4\u20136 10\u20100 nylon sutures. Evaluation was performed at 1 and 6 weeks after surgery, and included qualitative and semiquantitative light microscopy. LANR performed with a protein solder results in a good early peripheral nerve regeneration, with an optimal alignment of nerve fibers and minimal connective tissue proliferation at the repair site. All three suture materials produced a foreign body reaction; the least severe was with polyglycolic acid sutures. CMSR resulted in more pronounced foreign\u2010body granulomas at the repair site, with more connective\u2010tissue proliferation and axonal misalignment. Furthermore, axonal regeneration in the distal nerve segment was better in the laser groups. Based on these results, CO<jats:sub>2<\/jats:sub> laser\u2010assisted nerve repair with soldering in combination with absorbable sutures has the potential of allowing healing to occur with the least foreign\u2010body reaction at the repair site. Further experiments using this combination are in progress. \u00a9 2003 Wiley\u2010Liss, Inc. MICROSURGERY 23:109\u2013116 2003<\/jats:p>","DOI":"10.1002\/micr.10100","type":"journal-article","created":{"date-parts":[[2003,5,7]],"date-time":"2003-05-07T10:02:35Z","timestamp":1052301755000},"page":"109-116","source":"Crossref","is-referenced-by-count":32,"title":["Carbon dioxide laser\u2010assisted nerve repair: Effect of solder and suture material on nerve regeneration in rat sciatic nerve"],"prefix":"10.1002","volume":"23","author":[{"given":"Tomas","family":"Menovsky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan F.","family":"Beek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,5,5]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01402175"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/micr.1920140210"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(77)80008-7"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00383873"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1989.71.2.0266"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-198603000-00002"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199072050-00011"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-198508000-00009"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(84)80050-7"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/019459989210600405"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/micr.1920140609"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/019459989210700103"},{"key":"e_1_2_1_14_2","first-page":"1","article-title":"Peripheral nerve suture. Techniques for improved intraneural topography evaluation of some suture materials","volume":"331","author":"Edshage S","year":"1964","journal-title":"Acta Chir Scand [Suppl]"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9101(1997)20:1<64::AID-LSM10>3.0.CO;2-9"},{"key":"e_1_2_1_16_2","first-page":"22","article-title":"Peripheral nerve repair using the cw Ho:YAG (2.09 \u03bcm) laser and a protein solder","volume":"7","author":"Menovsky T","year":"1995","journal-title":"Lasers Surg Med [Suppl]"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/micr.1920150112"},{"key":"e_1_2_1_18_2","first-page":"16","article-title":"CO2 and Nd:YAG laser\u2010assisted nerve repair: a study of bonding strength and thermal damage","volume":"42","author":"Menovsky T","year":"2000","journal-title":"Acta Chir Plast"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/micr.1920160714"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2752(1996)17:10<562::AID-MICR6>3.0.CO;2-S"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2752(2000)20:3<150::AID-MICR10>3.0.CO;2-H"},{"key":"e_1_2_1_22_2","first-page":"120","article-title":"A modified staining method for connective tissue in semi\u2010thin histological sections of peripheral and cranial nerves","volume":"41","author":"Menovsky T","year":"2000","journal-title":"Acta Chir Plast"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(85)70213-7"},{"key":"e_1_2_1_24_2","doi-asserted-by":"crossref","first-page":"659","DOI":"10.2106\/00004623-196749040-00008","article-title":"Peripheral nerve repair in cats. The fascicular stitch","volume":"49","author":"Bora FJ","year":"1967","journal-title":"J Bone Joint Surg [Am]"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-197508000-00008"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.18003915516"},{"key":"e_1_2_1_27_2","first-page":"884","article-title":"Experimental comparison of suture materials in repair of small nerves","volume":"45","author":"Granberry W","year":"1963","journal-title":"J Bone Joint Surg [Am]"},{"key":"e_1_2_1_28_2","unstructured":"VuursteenPJ.De zenuwnaad. Een experimenteel onderzoek. Academic thesis University of Amsterdam 1983."},{"key":"e_1_2_1_29_2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1017\/S0317167100019934","article-title":"Polyglycolic acid suture in peripheral nerve: an electron microscopic study","volume":"2","author":"Hudson AR","year":"1975","journal-title":"Can J Neurol Sci"},{"key":"e_1_2_1_30_2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1017\/S0317167100026032","article-title":"Polyglycolic acid suture in peripheral nerve II: sutured sciatic nerve","volume":"3","author":"Hudson AR","year":"1976","journal-title":"Can J Neurol Sci"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(81)90186-4"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(84)80238-5"},{"key":"e_1_2_1_33_2","first-page":"358","volume-title":"Photodynamic therapy and biomedical lasers","author":"Al\u2010Hussaini AA","year":"1992"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0901-5027(89)80017-7"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1900170108"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199002000-00005"}],"container-title":["Microsurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmicr.10100","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/micr.10100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T01:10:33Z","timestamp":1700269833000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/micr.10100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,1]]}},"alternative-id":["10.1002\/micr.10100"],"URL":"https:\/\/doi.org\/10.1002\/micr.10100","archive":["Portico"],"relation":{},"ISSN":["0738-1085","1098-2752"],"issn-type":[{"value":"0738-1085","type":"print"},{"value":"1098-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,1]]}}}