{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T10:49:13Z","timestamp":1769597353799,"version":"3.49.0"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2003,10,8]],"date-time":"2003-10-08T00:00:00Z","timestamp":1065571200000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microsurgery"],"published-print":{"date-parts":[[2003,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of our study was to investigate the healing process after vasectomy reversal, comparing two suturing techniques. Eighty Wistar rats received a two\u2010layer vaso\u2010vasostomy on the right side, and 40 of them also received a single\u2010layer vaso\u2010vasostomy on the left side. Twenty rats each time were sacrificed at 30, 45, 60, and 90 days. Results were evaluated in order to compare the two techniques used and to describe the progression of healing, with special reference to anastomotic patency rate, histologic aspect of the epididymus and testicle, and the presence and size of spermatic granuloma. We observed 45% patency with the double\u2010layer technique compared to 20% with the single\u2010layer technique. The testicle appeared atrophic in 20% of double\u2010layer cases compared to 40% of single\u2010layer cases. Comparison over time showed a progressive increase in patency of the anastomosis, reduction of spermatic granuloma, and regression of testicular damage. Our results show the superiority of the double\u2010layer technique, and contribute to an understanding of the role of two different suturing techniques in the outcome of vasectomy reversal. \u00a9 2003 Wiley\u2010Liss, Inc. MICROSURGERY 23:437\u2013439 2003<\/jats:p>","DOI":"10.1002\/micr.10179","type":"journal-article","created":{"date-parts":[[2003,10,10]],"date-time":"2003-10-10T23:02:12Z","timestamp":1065826932000},"page":"437-439","source":"Crossref","is-referenced-by-count":2,"title":["Vasectomy reversal and spermatic granuloma: Experimental investigation"],"prefix":"10.1002","volume":"23","author":[{"given":"Giuseppe","family":"Cavallaro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Cavallaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)68819-2"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001200050348"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(97)81870-5"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)64504-X"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a136896"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(02)01888-5"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0094-0143(21)01260-X","article-title":"Reversal of vasectomy and the treatment of male infertility","volume":"8","author":"Silber SJ","year":"1981","journal-title":"Urol Clin North Am"},{"key":"e_1_2_1_9_2","first-page":"2097","article-title":"Vaso\u2010vasostomia termino\u2010terminale e granuloma spermatico. Ricerche sperimentali nel ratto. [End\u2010to\u2010end vasovasostomy and spermatic granuloma. Experimental research in the rat.]","volume":"37","author":"Cavallaro G","year":"1982","journal-title":"Minerva Chir"},{"key":"e_1_2_1_10_2","first-page":"385","article-title":"Experience with microsurgical two\u2010layer vasovasostomy","volume":"29","author":"Hirao Y","year":"1983","journal-title":"Hinyokika Kiyo"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)38381-7"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/S0022-5347(17)42661-9","article-title":"Effects of granuloma formation at site of vasovasostomy","volume":"139","author":"Carey PO","year":"1988","journal-title":"J Urol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2353(1996)9:5<302::AID-CA3>3.0.CO;2-E"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.2002.tb02312.x"}],"container-title":["Microsurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmicr.10179","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/micr.10179","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T00:51:47Z","timestamp":1700268707000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/micr.10179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,10]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2003,10]]}},"alternative-id":["10.1002\/micr.10179"],"URL":"https:\/\/doi.org\/10.1002\/micr.10179","archive":["Portico"],"relation":{},"ISSN":["0738-1085","1098-2752"],"issn-type":[{"value":"0738-1085","type":"print"},{"value":"1098-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,10]]}}}