{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T10:00:47Z","timestamp":1698055247040},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,10,19]],"date-time":"2005-10-19T00:00:00Z","timestamp":1129680000000},"content-version":"vor","delay-in-days":7596,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microsurgery"],"published-print":{"date-parts":[[1985,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In previous studies, we have shown that vascularized spleen grafts can facilitate the acceptance of simultaneously implanted hearts, especially if host splenectomy is done 3 days later. <jats:sup>1<\/jats:sup> The present study shows that the same protocol works not only for hearts but also for kidneys. A total of 59 renal allografts were carried out in various combinations between LEW and ACI rats. The recipients were submitted to bilateral nephrectomy at the time of graft implantation and host splenectomy 3 days later. Graft function was assessed by survival time of the animals. In addition, BUN, creatinine, and hematocrit were measured in selected individuals. The following observations were made: (1) LEW kidneys were rejected at 92 \u00b1 65 days while ACI kidneys failed at 17 \u00b1 1.4 days (p &lt; 0.025). (2) Control animals without simultaneous syngenic functioning spleen implant rejected their LEW kidneys at 30.6 \u00b1 24.3 days (p &lt; 0.005). (3) Eleven rats never rejected their LEW kidneys (four single, seven twin grafts). (4) BUN, creatinine, and hematocrit differed significantly in rats with functioning kidneys compared to those in end stage renal failure (p &lt; 0.0005, p &lt; 0.0025, and p &lt; 10 <jats:sup>\u22127<\/jats:sup> respectively). It is concluded that the presence of the donor spleen can facilitate the acceptance of a simultaneous kidney graft to various degrees, depending on the strain combination.<\/jats:p>","DOI":"10.1002\/micr.1920060105","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T16:05:40Z","timestamp":1173024340000},"page":"26-31","source":"Crossref","is-referenced-by-count":3,"title":["Kidney and spleen twin grafts in rats: Unidirectional graft acceptance in unsuppressed ACI recipients"],"prefix":"10.1002","volume":"6","author":[{"given":"J. M.","family":"Blanchard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. W.","family":"Tauber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. J.","family":"Welsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"John","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/micr.1920020407"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/micr.1920040312"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/micr.1920040407"},{"key":"e_1_2_1_5_2","first-page":"904","article-title":"Microvascular surgical technique in research, with special reference to renal transplantation in the rat","volume":"58","author":"Fisher B","year":"1965","journal-title":"Surgery"},{"key":"e_1_2_1_6_2","first-page":"771","article-title":"An improved technique for renal transplantation in the rat","volume":"61","author":"Lee S","year":"1967","journal-title":"Surgery"},{"key":"e_1_2_1_7_2","first-page":"436","article-title":"A technique for splenic transplantation in the rat","volume":"65","author":"Lee S","year":"1969","journal-title":"Surger"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-196907000-00030"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/micr.1920010509"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/clinchem\/18.8.829","article-title":"Enzymatic kinetic rate and end\u2010point analysis of substrate, by use of a GEMSAEC fast analyzer","volume":"18","author":"Tiffany TO","year":"1972","journal-title":"Clin Chem"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1093\/clinchem\/17.8.696","article-title":"Automated reaction rate method for determination of serum creatinine with the CentifiChem","volume":"17","author":"Fabiny DL","year":"1971","journal-title":"Clin Chem"},{"key":"e_1_2_1_12_2","first-page":"37","article-title":"True mechanism of immunologic enhancement. deduced from studies of heart transplants in rats","volume":"8","author":"Davies DAL","year":"1976","journal-title":"Transplant Proc"},{"key":"e_1_2_1_13_2","first-page":"349","article-title":"Studies on living cells harvested from acutely rejecting and enhanced rat cardiac allografts","volume":"26","author":"Tilney NL","year":"1975","journal-title":"Surg Forum"},{"key":"e_1_2_1_14_2","first-page":"271","article-title":"Immunologic enhancement of rat renal allografts","volume":"75","author":"Abbas AK","year":"1974","journal-title":"Am J Pathol"},{"key":"e_1_2_1_15_2","first-page":"183","article-title":"Effect of uremia on organ graft survival in the rat","volume":"54","author":"Souhami RL","year":"1973","journal-title":"Br J Exp Pathol"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(81)90043-X"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198403000-00011"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"50","DOI":"10.4049\/jimmunol.132.1.50","article-title":"High frequency of splenic anti\u2010class I cytotoxic T\u2010lymphocyte precursors correlated with in vivo rejection of K\/D region disparate thyroid and islet grafts in mice","volume":"132","author":"Isakov N","year":"1984","journal-title":"J Immunol"}],"container-title":["Microsurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmicr.1920060105","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/micr.1920060105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T15:22:41Z","timestamp":1697815361000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/micr.1920060105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1985,1]]}},"alternative-id":["10.1002\/micr.1920060105"],"URL":"https:\/\/doi.org\/10.1002\/micr.1920060105","archive":["Portico"],"relation":{},"ISSN":["0738-1085","1098-2752"],"issn-type":[{"value":"0738-1085","type":"print"},{"value":"1098-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,1]]}}}