{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T13:11:35Z","timestamp":1698066695769},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,10,19]],"date-time":"2005-10-19T00:00:00Z","timestamp":1129680000000},"content-version":"vor","delay-in-days":5770,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microsurgery"],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cross\u2010carotid microvascular bypass grafts 2\u20133 mm in diameter were implanted using microsurgical techniques for end\u2010to\u2010end anastomosis in four dogs. One autograft control and one of three denatured human umbilical artery xenografts (HUAG) were patent at 5 weeks. One of the other two denatured HUAGs had thrombosed at 1 week, and the other was occluded at 5 weeks. Host and graft vessel specimens were evaluated histologically as well as with transmission electron microscopy after sacrifice. Results indicate that failure of reconstitution of a true endothelial layer, presence of a subintimal myofibroblast population, increased collagen deposition of the muscularis, and occlusion of the adventitial and mural microcirculation were observed in both the early and late nonpatent vessels but not in the patent specimens. Evidence for myointimal cell proliferation was present in both patent and occluded grafts. A cohesive intimal layer was observed in both patent cases. Microvascular occlusion, due to an excess of endothelial cells, of new vasa vasorum in one case seems related to increased fibrosis, which could have resulted in graft stenosis. The surgical procedures and subsequent morphological analyses were adequate and sufficient for use in a longterm study of the possible causes of graft failure.<\/jats:p>","DOI":"10.1002\/micr.1920110108","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T19:30:54Z","timestamp":1173036654000},"page":"34-39","source":"Crossref","is-referenced-by-count":3,"title":["Morphological studies of cellular responses to experimental arterial grafts"],"prefix":"10.1002","volume":"11","author":[{"given":"C. Ward","family":"Kischer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip R.","family":"Weinstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Spall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Brendel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-198109000-00009"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197508000-00010"},{"key":"e_1_2_1_4_2","first-page":"851","article-title":"Endothelialization of a new arterial microvascular graft material","volume":"3","author":"Mehdorn HM","year":"1979","journal-title":"Scanning Electron Microsc"},{"key":"e_1_2_1_5_2","first-page":"177","article-title":"Expanded microporous polytetraflouroethylene as a vascular substitute: A two year follow\u2010up","volume":"85","author":"Campbell CD","year":"1979","journal-title":"Surgery"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-197611000-00012"},{"key":"e_1_2_1_7_2","first-page":"33","volume-title":"The Cerebral Vessel Wall","author":"Nelson E","year":"1976"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","unstructured":"BrendelK DuhamelRC MaloneJM ReinertRL:Acellular vascular matrix as a small diameter vascular graft inHEKambie AKantrowitz PSung(eds):Vascular Graft Update: Safety and Performance ASTM STP 898.Philadelphia American Society for Testing and Materials 1986 pp219\u2013235.","DOI":"10.1520\/STP33294S"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(82)80078-6"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4800(70)90084-5"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00594710"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(84)80185-9"}],"container-title":["Microsurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmicr.1920110108","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/micr.1920110108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T16:50:38Z","timestamp":1697993438000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/micr.1920110108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,1]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1990,1]]}},"alternative-id":["10.1002\/micr.1920110108"],"URL":"https:\/\/doi.org\/10.1002\/micr.1920110108","archive":["Portico"],"relation":{},"ISSN":["0738-1085","1098-2752"],"issn-type":[{"value":"0738-1085","type":"print"},{"value":"1098-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,1]]}}}