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Anticoagulants, platelet anti\u2010aggregation agents, and fibrinolytic agents were evaluated for their influence upon the developing thrombus, utilizing scanning electron microscopy to determine thrombus surface composition. These agents included: heparin, aspirin, dextran 40, streptokinase, and prostacyclin. The results are consistent with the known nature of each of these agents. When two agents were given simultaneously, each acting on different aspects of thrombogenesis (platelets vs. fibrin), the outcome appeared synergistic, with substantial reduction in thrombus accumulation; clear inhibition of both platelet aggregation and fibrin polymerization was noted. These findings support the clinical use of two agents used simultaneously, one inhibiting fibrin strand formation and the other inhibiting platelet adherence\/aggregation, for the prevention of micro\u2010arterial thrombosis.<\/jats:p>","DOI":"10.1002\/micr.1920120413","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T20:05:42Z","timestamp":1173038742000},"page":"292-300","source":"Crossref","is-referenced-by-count":14,"title":["Evaluation of the effect of pharmacologic agents on crush\u2010avulsion arterial injuries: A scanning electron microscopy study"],"prefix":"10.1002","volume":"12","author":[{"given":"F. 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