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For 7 prior and 4, 7, 14, 21, and 30 days posttransplantation (during which the animals were housed in metabolic cages for periods of 24 hours) body weight, water and food intake, urine output, blood and urinary glucose, plasma insulin, and glucagon were recorded. These parameters were also concurrently recorded for diabetic and nondiabetic control rats. Animals were sacrificed after 30 days and histological and immunohistochemical studies of the pancreas were performed. Pancreatic transplants consistently and significantly improved the metabolic abnormalities of the diabetic rat (<jats:italic>P<\/jats:italic>&lt;0.01) by restoring body weight gain, and by immediate relief of hyperglycemia, glucosuria, polyuria, polydipsia, and also the low levels of plasma insulin. The plasma glucagon, elevated in diabetic control rats, did not change after transplant. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/micr.1920130307","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T20:37:31Z","timestamp":1173040651000},"page":"132-137","source":"Crossref","is-referenced-by-count":5,"title":["Metabolic effect of pancreaticoduodenal transplantation in diabetic rats"],"prefix":"10.1002","volume":"13","author":[{"given":"C\u00e9sar T.","family":"Spadella","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz C.","family":"Breim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria C. 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