{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,17]],"date-time":"2025-05-17T06:31:29Z","timestamp":1747463489363},"reference-count":9,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,10,19]],"date-time":"2005-10-19T00:00:00Z","timestamp":1129680000000},"content-version":"vor","delay-in-days":4674,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microsurgery"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In plastic surgery, free skeletal muscle flaps are used for treatment of non\u2010healing injuries like chronic osteitis or radiation ulcers. We wanted to evaluate if the neoangiogenesis induced by these flaps can also constitute a method for revascularization in ischemic heart disease. In diffuse small vessel coronary heart disease, patients are not suitable for bypass surgery because it is impossible to create a microanastomosis with the coronary artery. As an alternative, a free striated muscle flap, transplanted onto the heart, can constitute a source of neovessels. With the induction of extra\u2010intracardial collaterals that develop within 4 weeks after transplantation of the flap, a new surgical approach may be offered to those patients. Our experimental work was performed with 20 dogs. In these, a myocardial infarction of the anterior wall was selectively produced using the Judkins\u2010technique (<jats:italic>Radiology<\/jats:italic> 89: 815\u2013824, 1967) for injection of Sephadex\u2010microspheres. Four weeks later a free pectoralis muscle flap was transplanted onto the anterior wall of the heart. Arterial blood supply was achieved with an anastomosis with the internal mammary artery. The venous flow was directed into the right atrium. Four to eight weeks after surgery, the patency of the anastomosis was studied by angiography, showing patency in almost all surviving animals. Histological examination of the hearts revealed a prominent vascular network penetrating into the underlying myocardium. Corrosion cast preparations, as well as a postmortem angiography, showed even further penetration of the neovessels into the uninjured parts of the myocardium. Thus, myocardial revascularization may be achieved by transplantation of a skeletal muscle onto the heart. \u00a9 1993 Wiley\u2010Liss Inc.<\/jats:p>","DOI":"10.1002\/micr.1920140208","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T21:25:02Z","timestamp":1173043502000},"page":"125-129","source":"Crossref","is-referenced-by-count":6,"title":["Free skeletal muscle transplantation to an infarction area: An experimental study in the dog."],"prefix":"10.1002","volume":"14","author":[{"given":"Michael","family":"Beyer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald","family":"Hoffer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Eggeling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Otto","family":"Matt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Beyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Hannekum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1148\/89.5.815"},{"key":"e_1_2_1_3_2","volume-title":"Biomechanical Cardiac Assist. Cardiomyoplasty and Muscle\u2010Powered Devices","author":"Walsh G","year":"1986"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02576272"},{"key":"e_1_2_1_5_2","unstructured":"BeyerM HofferH BeyerU EggelingT MierdlS HannekumA: Cardiac arrhythmias during the experimental production of a myocardial infarction in the dog.Exp Anim Sci 1992(in press)."},{"key":"e_1_2_1_6_2","unstructured":"BeyerM HofferH HannekumA: Angiography performed on a free muscle transplant onto the infarcted myocard in the dog.Presented at \u201cCoronary Artery Surgery in Arge Alp and Pentagonale 1991\u201d Salzburg (Austria) May 30\u2010June 1 Book of Abstract pp.30."},{"key":"e_1_2_1_7_2","first-page":"132","article-title":"Neoangiogenese nach Transplantation eines Skelettmuskellappens auf das Myokard des Hundes","volume":"21","author":"Beyer M","year":"1992","journal-title":"J Vas Dis VASA"},{"key":"e_1_2_1_8_2","first-page":"189","article-title":"Cardiomyoplasty to improve collateral blood supply as an alternative to transplantation in intractable angina","volume":"4","author":"Beyer M","year":"1992","journal-title":"Heart Lung Transplantation"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.71.2.341"},{"key":"e_1_2_1_10_2","first-page":"121","volume-title":"Biomechanical Cardiac Assist. Cardiomyoplasty and Muscle\u2010Powered Devices","author":"Goldberg NH","year":"1986"}],"container-title":["Microsurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmicr.1920140208","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/micr.1920140208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T21:18:50Z","timestamp":1698182330000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/micr.1920140208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1993,1]]}},"alternative-id":["10.1002\/micr.1920140208"],"URL":"https:\/\/doi.org\/10.1002\/micr.1920140208","archive":["Portico"],"relation":{},"ISSN":["0738-1085","1098-2752"],"issn-type":[{"value":"0738-1085","type":"print"},{"value":"1098-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,1]]}}}