{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T09:45:57Z","timestamp":1776764757198,"version":"3.51.2"},"reference-count":8,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,12,11]],"date-time":"2005-12-11T00:00:00Z","timestamp":1134259200000},"content-version":"vor","delay-in-days":4362,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microsurgery"],"published-print":{"date-parts":[[1994,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>After primary repair of lesions of nerves and vessels, patients who were administered a vasoactive drug, naftidrofuryl, postoperatively, had a better functional recovery than untreated patients. Evidence for the favourable effect of the drug on nerve regeneration was first obtained from experiments in the rat. The sciatic nerve was transected and repaired with standard microsurgical techniques. Results were evaluated by electromyography and histology. Data indicated that treated animals had better motor responses and distal latency than untreated rats. Fibre counts showed a greater number of nerve fibres in the distal stump of treated animals. The clinical study was undertaken in cases of carpal tunnel syndrome with muscle atrophy. Assessment was performed by electrophysiology: motor and sensory conduction was studied. Data showed that all treated patients recovered totally or partially from the thenar atrophy they presented before operation, whereas thenar atrophy persisted in 37% of the patients receiving placebo. In conclusion, naftidrofuryl has an experimentally and clinically favourable effect on nerve regeneration and on muscle trophicity, but the mechanism of action of this drug is not known.<\/jats:p>","DOI":"10.1002\/micr.1920150308","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T22:36:47Z","timestamp":1173047807000},"page":"179-186","source":"Crossref","is-referenced-by-count":4,"title":["Experimental and clinical study of the effect of naftidrofuryl on the recovery from peripheral nerve lesions"],"prefix":"10.1002","volume":"15","author":[{"given":"Michel","family":"Merle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Fran\u00e7ois","family":"Fredenucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Petry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Foliguet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Mosnier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"761","article-title":"Playdoyer pour la r\u00e9paration primaire microchirurgicale des l\u00e9sions des nerfs p\u00e9riph\u00e9riques. Etude comparative de 150 l\u00e9sions du nerf m\u00e9dian et du nerf cubital avec un recul sup\u00e9rieur \u00e0 2 ans","volume":"110","author":"Merle M","year":"1984","journal-title":"Chirurgie"},{"key":"e_1_2_1_3_2","article-title":"Un nouveau promoteur de croissance nerveuse: Le Naftidrofuryl","volume":"302","author":"Hauw JJ","year":"1986","journal-title":"C.R. Acad\u00e9mie des Sciences, Paris"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00965509"},{"key":"e_1_2_1_5_2","first-page":"315","article-title":"Am\u00e9lioration de la polyn\u00e9urite diab\u00e9tique sous naftidrofuryl","volume":"46","author":"Doucet J","year":"1991","journal-title":"Th\u00e9rapie"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.2307\/3001535"},{"key":"e_1_2_1_7_2","volume-title":"Rank Correlation Methods","author":"Kendall MG","year":"1955"},{"key":"e_1_2_1_8_2","volume-title":"Non\u2010parametric Statistics for the Behavioral Sciences","author":"Siegle S"},{"key":"e_1_2_1_9_2","volume-title":"Principles of Experimental Design","author":"Winer JB","year":"1972"}],"container-title":["Microsurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmicr.1920150308","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/micr.1920150308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T12:20:26Z","timestamp":1698236426000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/micr.1920150308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,1]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1994,1]]}},"alternative-id":["10.1002\/micr.1920150308"],"URL":"https:\/\/doi.org\/10.1002\/micr.1920150308","archive":["Portico"],"relation":{},"ISSN":["0738-1085","1098-2752"],"issn-type":[{"value":"0738-1085","type":"print"},{"value":"1098-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,1]]}}}