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Bone scintigram and radiographs were used as an indicator for early detection of rejection after transplantation and bone union. In vascularized bone allografts under long\u2010term immunosuppression with cyclosporin A, early bone union and continuous incorporation were similar to that observed in vascularized bone autograft transplantation. When administration of cyclosporin A was discontinued before completion of bone union, the graft was rejected and bone union was delayed. Apparent swelling on the operated limb associated with a decrease in bone scintigram uptake suggested the occurrence of rejection of the allograft. Vascularized bone allograft transplantation is useful for reconstruction of massive bone defects only if immunosuppressants are used and maintained at least until bone union is obtained. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/micr.1920150913","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T23:14:32Z","timestamp":1173050072000},"page":"663-670","source":"Crossref","is-referenced-by-count":18,"title":["Experimental study on vascularized bone allografts for reconstruction of massive bone defects"],"prefix":"10.1002","volume":"15","author":[{"given":"Mitsunori","family":"Shigetomi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuteru","family":"Doi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyuki","family":"Kuwata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Muramatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00451315"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198503000-00009"},{"key":"e_1_2_1_4_2","first-page":"564","article-title":"Microsurgically revascularized bone allografts with immunosuppression with cyclosporine: Preliminary report of the effect in an animal model","volume":"42","author":"Aebi M","year":"1986","journal-title":"Transplantation"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198769030-00013"},{"key":"e_1_2_1_6_2","first-page":"3191","article-title":"Prolonged limb\u2010allograft survival with short\u2010term treatment with FK506 in rats","volume":"21","author":"Arai K","year":"1989","journal-title":"Transplant Proc"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198906000-00017"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1302\/0301-620X.71B4.2768300","article-title":"The effect of immunosuppression on vascularised allografts. 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