{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:35:30Z","timestamp":1767706530939},"reference-count":12,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,10,19]],"date-time":"2005-10-19T00:00:00Z","timestamp":1129680000000},"content-version":"vor","delay-in-days":3944,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microsurgery"],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effects of topical GM1 ganglioside on crushed rat sciatic nerve regeneration were studied in this presentation. Thirty\u2010four rats, with 68 bilateral sciatic nerves, were divided into seven groups: one group of four rats for measurement of normal motor nerve conduction velocity (MNCV), three as controls, and another three in the GM1\u2010treated groups. Sciatic nerves were exposed and crushed at a site 6 mm distal to the sciatic notch by the standard technique. In this manner, 3 mm wide crush injuries were created. Then 2.1 \u03bcl of normal saline was injected into the crush site in the control groups and an equal volume of GM1 solution (containing 10 \u03bcg GM1) was injected into the GM1\u2010treated groups. Electrophysiological, histological, and morphometric evaluations were carried out at 12, 28, and 56 days. A significantly higher muscle action potential (MAP) rate was found in the GM1\u2010treated group (70%) vs. the controls (none) at 12 days (<jats:italic>P<\/jats:italic>&lt;0.005), and increased MNCV was found in the GM1\u2010treated groups at both 28 and 56 days, especially at 56 days, when it was 39.59 \u00b1 9.23 m\/sec vs. 31.42 \u00b1 4.07 m\/sec in controls (<jats:italic>P<\/jats:italic>&lt;0.05). Morphometrically, there were more regenerated myelinated fibers (RMFs) at 12 days, and larger diameter of RMFs were observed at 12, 28, and 56 days in the GM1\u2010treated groups. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/micr.1920160807","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T00:38:43Z","timestamp":1173055123000},"page":"542-546","source":"Crossref","is-referenced-by-count":8,"title":["Topical GM1 ganglioside to promote crushed rat sciatic nerve regeneration"],"prefix":"10.1002","volume":"16","author":[{"given":"Min\u2010Sheng","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong\u2010Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang\u2010Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng\u2010Rong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(85)90144-0"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02842941"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199005000-00004"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1523\/JNEUROSCI.08-03-00746.1988","article-title":"Development and survival of neurons in dissociated mesencephalic serum\u2010free cell cultures: II. Modulatory effects of gangliosides","volume":"8","author":"Leon A","year":"1988","journal-title":"J Neurosci"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7291999"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4886(84)90094-3"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(87)90081-1"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/micr.1920130310"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(88)90170-8"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)91732-G"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)90451-5"},{"key":"e_1_2_1_13_2","first-page":"99","volume-title":"Gangliosides in Neurological and Neuromuscular Function","author":"Seifert W","year":"1981"}],"container-title":["Microsurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmicr.1920160807","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/micr.1920160807","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:31:06Z","timestamp":1698366666000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/micr.1920160807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,1]]},"references-count":12,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1995,1]]}},"alternative-id":["10.1002\/micr.1920160807"],"URL":"https:\/\/doi.org\/10.1002\/micr.1920160807","archive":["Portico"],"relation":{},"ISSN":["0738-1085","1098-2752"],"issn-type":[{"value":"0738-1085","type":"print"},{"value":"1098-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,1]]}}}