{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:06:32Z","timestamp":1792098392410,"version":"4.4.0"},"reference-count":12,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,10,19]],"date-time":"2005-10-19T00:00:00Z","timestamp":1129680000000},"content-version":"vor","delay-in-days":3944,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microsurgery"],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effects of nerve growth factor (NGF) on crushed sciatic nerve regeneration were studied in 30 rats, with 60 bilateral nerves. The nerves were crushed at a site 6 mm distal to the sciatic notch by the standard technique and 3 mm wide crush injuries were created. Then 2.1 \u03bcl of normal saline in the control groups and an equal volume of NGF solution (containing 1 \u03bcg of NGF) in the NGF\u2010treated groups was injected into the crush sites and followed for 12, 28, and 56 days, respectively. At the end of the observation, electrophysiological evaluation was carried out; then samples 10 mm distal to the crush site were removed and prepared for histological and morphometric studies. Evoked muscle action potential (MAP) was recorded in 50% of the NGF\u2010treated group at 12 days but not in the control group; the difference was statistically significant (<jats:italic>P<\/jats:italic>&lt;0.05). The motor nerve conduction velocity (MNCV) was increased in NGF\u2010treated groups compared with control groups at 28 and 56 days (<jats:italic>P<\/jats:italic>&lt;0.05). Morphometrically, significantly more regenerated myelinated fibers (RMFs) were seen at 12 days, and larger diameter RMFs were found at 12, 28, and 56 days in NGF\u2010treated groups than in control groups. These results indicate that topically applied NGF stimulates nerve regeneration and promotes function recovery in crushed rat sciatic nerves. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/micr.1920160808","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T00:38:43Z","timestamp":1173055123000},"page":"547-551","source":"Crossref","is-referenced-by-count":26,"title":["Effects of nerve growth factor on crushed sciatic nerve regeneration in rats"],"prefix":"10.1002","volume":"16","author":[{"given":"Zhong\u2010Wei","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min\u2010Sheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,10,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401160206"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6171034"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(91)90665-G"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/micr.1920130310"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1523\/JNEUROSCI.08-02-00664.1988","article-title":"Expression of nerve growth factor receptor by Schwann cells of axotomized peripheral nerves: Ultrastructural location, suppression by axonal contact and binding properties","volume":"812","author":"Taniuchi M","year":"1988","journal-title":"J Neurosci"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.104.6.1623"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.23.8735"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1993.1019"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(89)90184-2"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)91289-1"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880060402"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880070305"}],"container-title":["Microsurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmicr.1920160808","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/micr.1920160808","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:31:08Z","timestamp":1698366668000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/micr.1920160808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,1]]},"references-count":12,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1995,1]]}},"alternative-id":["10.1002\/micr.1920160808"],"URL":"https:\/\/doi.org\/10.1002\/micr.1920160808","archive":["Portico"],"relation":{},"ISSN":["0738-1085","1098-2752"],"issn-type":[{"value":"0738-1085","type":"print"},{"value":"1098-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,1]]}}}