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Rats received 3 mg\/kg 1400W, 10 mg\/kg 1400W, or water subcutaneously. Results showed that EDL contractile function in both 1400W\u2010treated groups significantly outperformed the controls at 24\u2010h but not at 3\u2010h reperfusion. Although iNOS expression increased in all three I\/R groups during reperfusion, a significantly smaller increase was found in 1400W\u2010treated muscles after 3\u2010h reperfusion, and more dramatically so after 24\u2010h reperfusion. Our results indicate that inhibition of iNOS preserved the contractile function in reperfused skeletal muscle, perhaps via downregulating iNOS expression. Protection by 1400W at 24\u2010h reperfusion suggests that the role of iNOS in exaggerating reperfusion injury is more prominent in the later stages of injury. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/micr.20029","type":"journal-article","created":{"date-parts":[[2004,5,18]],"date-time":"2004-05-18T23:01:04Z","timestamp":1084921264000},"page":"324-331","source":"Crossref","is-referenced-by-count":23,"title":["Inhibition of iNOS with 1400W improves contractile function and alters nos gene and protein expression in reperfused skeletal muscle"],"prefix":"10.1002","volume":"24","author":[{"given":"Prerana","family":"Patel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Ning","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane 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