{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T05:33:00Z","timestamp":1782624780932,"version":"3.54.5"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,27]],"date-time":"2006-01-27T00:00:00Z","timestamp":1138320000000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microsurgery"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>One of the main problems of microsurgery for lymphedema consists of the discrepancy between the excellent technical possibilities and the subsequently insufficient reduction of the lymphoedematous tissue fibrosis and sclerosis. Appropriate treatment based on pathologic study and surgical outcome have not been adequately documented. Over the past 25 years, more than 1000 patients with peripheral lymphedema have been treated with microsurgical techniques. Derivative lymphatic micro\u2010vascular procedures has today its most exemplary application in multiple lymphatic\u2010venous anastomoses (LVA). For those cases where a venous disease is associated to more or less latent or manifest lymphostatic pathology of such severity to contraindicate a lymphatic\u2010venous shunt, reconstructive lymphatic microsurgery techniques have been developed (autologous venous grafts or lymphatic\u2010venous\u2010Iymphatic\u2010plasty \u2010 LVLA). Objective assessment was undertaken by water volumetry and lymphoscintigraphy. Subjective improvement was noted in 87% of patients. Objectively, volume changes showed a significant improvement in 83%, with an average reduction of 67% of the excess volume. Of those patients followed\u2010up, 85% have been able to discontinue the use of conservative measures, with an average follow\u2010up of more than 7 years and average reduction in excess volume of 69%. There was a 87% reduction in the incidence of cellulitis after microsurgery. Microsurgical lymphatic\u2010venous anastomoses have a place in the treatment of peripheral lymphedema and should be the therapy of choice in patients who are not sufficiently responsive to nonsurgical treatment. Improved results can be expected with operations performed earlier at the very first stages of lymphedema. \u00a9 2006 Wiley\u2010Liss, Inc. Microsurgery 26: 65\u201369, 2006.<\/jats:p>","DOI":"10.1002\/micr.20214","type":"journal-article","created":{"date-parts":[[2006,1,28]],"date-time":"2006-01-28T00:48:20Z","timestamp":1138409300000},"page":"65-69","source":"Crossref","is-referenced-by-count":119,"title":["Lymphatic microsurgery for the treatment of lymphedema"],"prefix":"10.1002","volume":"26","author":[{"given":"C.","family":"Campisi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Davini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bellini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Taddei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Villa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Fulcheri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Zilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Da Rin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Eretta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Boccardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,1,27]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"13","article-title":"Lower\u2010limb chronic lymphedema and Stewart\u2010Treves syndrome","volume":"27","author":"Wienert V","year":"2000","journal-title":"Phlebolymphology"},{"key":"e_1_2_1_3_2","first-page":"43","article-title":"The therapy of lymphedema","volume":"14","author":"F\u00f6ldi M","year":"1993","journal-title":"Eur J Lymphol Rel Probl"},{"key":"e_1_2_1_4_2","volume-title":"Le drainage lymphatique. Th\u00e9orie et pratique","author":"Leduc A","year":"1980"},{"key":"e_1_2_1_5_2","first-page":"504","volume-title":"Lymphedema","author":"Charles RH","year":"1912"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S0039-6109(16)38188-9","article-title":"The surgical treatment of chronic lymphoedema of the extremities","volume":"47","author":"Thompson N","year":"1967","journal-title":"Surg Clin North Am"},{"key":"e_1_2_1_7_2","unstructured":"Servelle M. La lymphangiectomie superficielle totale. Traitement chirurgical de l'\u00e9l\u00e9phantiasis. Rev Chir 1947; 294."},{"key":"e_1_2_1_8_2","volume-title":"Il sistema linfatico nella pratica clinica","author":"Battezzati M","year":"1967"},{"key":"e_1_2_1_9_2","unstructured":"Belardi P. Terapia dei linfedemi. In: Casaccia M Campisi C editors. Lymphology: advances in Europe. Ecig Genoa. 1989. p 215\u2013 220."},{"key":"e_1_2_1_10_2","first-page":"312","article-title":"The treatment of lymphedema of the extremities with microsurgical lympho\u2010venous anastomoses","volume":"7","author":"Olszewski WL","year":"1988","journal-title":"Int Angiol"},{"key":"e_1_2_1_11_2","first-page":"6","article-title":"New techniques of lymphatic\u2010venous anastomosis for the treatment of lymphedema","volume":"14","author":"Degni M","year":"1981","journal-title":"Lymphology"},{"key":"e_1_2_1_12_2","volume-title":"Lymphedema","author":"Clodius L","year":"1977"},{"key":"e_1_2_1_13_2","first-page":"1711","article-title":"Anastomosi linfatico\u2010venose periferiche (nuova tecnica chirurgica)","volume":"33","author":"Clodius L","year":"1978","journal-title":"Minerva Chir"},{"key":"e_1_2_1_14_2","first-page":"48","article-title":"Rational approach in the management of lymphedema","volume":"24","author":"Campisi C","year":"1991","journal-title":"Lymphology"},{"key":"e_1_2_1_15_2","first-page":"47","article-title":"Role of microsurgery in the management of lymphoedema","volume":"18","author":"Campisi C","year":"1999","journal-title":"Int Angiol"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2752(1998)18:8<462::AID-MICR7>3.0.CO;2-C"},{"key":"e_1_2_1_17_2","volume-title":"Lymphatique profonds et lymphoed\u00e8mes chroniques des membres","author":"Tosatti E","year":"1974"},{"key":"e_1_2_1_18_2","volume-title":"The Lymphatics. Surgery, lymphography and diseases of the chyle and lymph systems","author":"Kinmonth JB","year":"1982"},{"key":"e_1_2_1_19_2","first-page":"14","article-title":"Lymphoedema: modern diagnostic and therapeutic aspects","volume":"18","author":"Campisi C","year":"1999","journal-title":"International Angiology"}],"container-title":["Microsurgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmicr.20214","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/micr.20214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T03:47:56Z","timestamp":1694576876000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/micr.20214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1002\/micr.20214"],"URL":"https:\/\/doi.org\/10.1002\/micr.20214","archive":["Portico"],"relation":{},"ISSN":["0738-1085","1098-2752"],"issn-type":[{"value":"0738-1085","type":"print"},{"value":"1098-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1]]}}}